A novel pyroptosis-related LncRNA signature predicts prognosis and indicates tumor immune microenvironment in skin cutaneous melanoma

Zhong, Jia'nan1; Wang, Zheng2; Hounye, Alphonse Houssou3; Liu, Jing4; Zhang, Jianglin5,6; Qi, Min7

2022-10-15

10.1016/j.lfs.2022.120832

LIFE SCIENCES   Impact Factor & Quartile

0024-3205

1879-0631

Aims: To explore the correlation between the pyroptosis-related lncRNAs (PRlncRNAs) and the prognosis of skin cutaneous melanoma (SKCM), and clarify the effects of the PRlncRNAs on the tumor immune infiltration. Main methods: In this study, we utilized RNA-seq and clinical characteristics data obtained from TCGA and GEO database to perform co-expression analysis and LASSO Cox regression analysis to construct a 12-PRlncRNA prognostic prediction model. We also performed functional analysis, immune infiltration analysis and drug sensitivity analysis, as well as correlation analysis with autophagy/ferroptosis genes, tumor mutational burden, and PD-1/PD-L1 genes. Key finding: The model based on the 12-PRlncRNA signature could effectively predict the prognosis of SKCM. Low risk group had a higher anti-tumor immune level generally compared with high-risk group. The signature was correlated with the expression of autophagy/ferroptosis-related genes and PD1/PD-L1 genes and tumor muta-tional burden. Additionally, drug sensitivity analysis indicated potential therapeutic targets. Significance: Our study demonstrated the impact of PRlncRNAs on SKCM. The model established based on the 12-PRlncRNA showed significant prognostic value for SKCM and may be instructive in pyroptosis-related targeted therapy in the clinic.

Pyroptosis Long non-coding RNAs Skin cutaneous melanoma (SKCM) Prognosis Tumor immune microenvironment

SCI

English

Corresponding

National Natural Science Foundation of China["82073019","82073018","61375063","61271355","11301549","11271378"] ; Hunan Provincial Nature Science Foundation of China[2022JJ30189] ; Teaching Reform Research Project of Universities inHunan Province[HNJG-2021-1120] ; Shenzhen Science and Tech-nology Innovation Commission, China (Natural Science Foundation of Shenzhen)["JCYJ20210324113001005","JCYJ20210324114212035"]

Research & Experimental Medicine ; Pharmacology & Pharmacy

Medicine, Research & Experimental ; Pharmacology & Pharmacy

WOS:000863982000001

PERGAMON-ELSEVIER SCIENCE LTD

BIOLOGY & BIOCHEMISTRY

Web of Science

1.Cent South Univ, Xiangya Hosp, Dept Dermatol, Changsha 410000, Peoples R China
2.Hunan First Normal Univ, Sch Comp Sci, Changsha 410205, Peoples R China
3.Cent South Univ, Sch Math & Stat, Changsha 410083, Peoples R China
4.Hunan Vocat Coll Engn, Dept Informat Engn, Changsha 410151, Peoples R China
5.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Dermatol,Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China
6.Natl Clin Res Ctr Skin Dis, Candidate Branch, Shenzhen 518020, Guangdong, Peoples R China
7.Cent South Univ, Xiangya Hosp, Dept Plast Surg, Changsha 410008, Peoples R China

Zhong, Jia'nan,Wang, Zheng,Hounye, Alphonse Houssou,et al. A novel pyroptosis-related LncRNA signature predicts prognosis and indicates tumor immune microenvironment in skin cutaneous melanoma[J]. LIFE SCIENCES,2022,307.

Zhong, Jia'nan,Wang, Zheng,Hounye, Alphonse Houssou,Liu, Jing,Zhang, Jianglin,&Qi, Min.(2022).A novel pyroptosis-related LncRNA signature predicts prognosis and indicates tumor immune microenvironment in skin cutaneous melanoma.LIFE SCIENCES,307.

Zhong, Jia'nan,et al."A novel pyroptosis-related LncRNA signature predicts prognosis and indicates tumor immune microenvironment in skin cutaneous melanoma".LIFE SCIENCES 307(2022).