Protein pyrrole adducts are associated with elevated glucose indices and clinical features of diabetic diffuse neuropathies

Chen, Xiao1; Jiang, Zhuyi2; Zhang, Lianjing1,3; Liu, Wei1; Ren, Xiaohu1; Nie, Luling1; Wu, Desheng1; Guo, Zhiwei4; Liu, Weimin5; Yang, Xifei1; Wu, Yan2; Liang, Zhen2; Spencer, Peter6; Liu, Jianjun1,3

2022-10-01

10.1111/1753-0407.13318

Journal of Diabetes   Impact Factor & Quartile

1753-0393

1753-0407

Introduction Diabetic neuropathy is the most prevalent complication of diabetes mellitus. Although the precise etiology of this neurological disorder has yet to be defined, elevated blood glucose promotes anerobic glycolysis; this produces excess advanced glycation end-products, many of which have a pyrrole structure. Here, we test the hypothesis that protein pyrrole adducts are associated with elevated glucose indices and some clinical features of diabetic diffuse neuropathies. Method We investigated the levels of plasma pyrrole adducts and adjusted urinary pyrrole adducts in a group of elderly persons (n = 516, age 60-79) residing in the District of Luohu, Shenzhen, China between 2017 and 2018. Symptoms of distal symmetric polyneuropathy (DSPN) and resting heart rate, a measure of autonomic nervous system function, were collected from participants (n = 258) with elevated glucose indices. Result Protein pyrrole adducts showed a strong correlation with glucose indices before and after adjustment for age and estimated glomerular filtration rates. Stratified analysis showed that the medians and interquartile values of pyrrole adducts grew as glucose indices of the subgroups increased. Participants with symptoms of DSPN and sinus tachycardia presented elevated levels of plasma pyrrole adducts. Conclusion This study provides a novel link between glucose indices and the etiology of diabetic diffuse neuropathies.

axonopathy diabetic neuropathy gamma-diketone protein pyrrole adduct

SCI

English

Corresponding

Guangdong Medical Science and Technology Research Fund[A2022438] ; Nature Science Foundation of China[81803209] ; Sanming Project of Medicine in Shenzhen[SZSM201611090] ; Shenzhen Key Medical Discipline Construction Fund[SZXK069]

Endocrinology & Metabolism

Endocrinology & Metabolism

WOS:000863762100001

WILEY

Web of Science

1.Shenzhen Ctr Dis Control & Prevent, Key Lab Modern Toxicol Shenzhen, Shenzhen Med Key Discipline Hlth Toxicol 2020 202, Shenzhen 518055, Guangdong, Peoples R China
2.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp,Clin Med Coll 2,Dept Endocr, Shenzhen 518020, Peoples R China
3.Guangdong Med Univ, Sch Publ Hlth, Dongguan, Peoples R China
4.Shenzhen Luohu Hosp Tradit Chinese Med, Shenzhen Luohu Hosp Grp, Shenzhen, Peoples R China
5.Shenzhen Luohu Ctr Dis Control & Prevent, Shenzhen, Peoples R China
6.Oregon Hlth & Sci Univ, Sch Med, Oregon Inst Occupat Hlth Sci, Dept Neurol, Portland, OR 97201 USA

Chen, Xiao,Jiang, Zhuyi,Zhang, Lianjing,et al. Protein pyrrole adducts are associated with elevated glucose indices and clinical features of diabetic diffuse neuropathies[J]. Journal of Diabetes,2022.

Chen, Xiao.,Jiang, Zhuyi.,Zhang, Lianjing.,Liu, Wei.,Ren, Xiaohu.,...&Liu, Jianjun.(2022).Protein pyrrole adducts are associated with elevated glucose indices and clinical features of diabetic diffuse neuropathies.Journal of Diabetes.

Chen, Xiao,et al."Protein pyrrole adducts are associated with elevated glucose indices and clinical features of diabetic diffuse neuropathies".Journal of Diabetes (2022).