中文版 | English
Title

Recent advances in small molecular near-infrared fluorescence probes for a targeted diagnosis of the Alzheimer disease

Author
Corresponding AuthorDeng, Yuanfei; Hu, Genwen; Guo, Bing
Publication Years
2022-09-01
DOI
Source Title
ISSN
0003-2654
EISSN
1364-5528
Abstract
Nowadays, it is still quite challenging to achieve an early diagnosis of the Alzheimer disease (AD) in clinics. The burgeoning near-infrared fluorescence (NIRF) imaging fulfills the requirements for a precise diagnosis with good sensitivity and a high signal-to-background ratio and offers opportunities for the efficient AD diagnosis. As the pathogenesis of AD is quite complex, there is an ongoing exploration of advanced probes to specifically target AD biomarkers (e.g., amyloid-beta (A beta) plaques, neurofibrillary tangles, viscosity, peroxynitrite (ONOO-), reactive oxygen species, and methylglyoxal). To this end, a great number of small molecular fluorescent probes with good water solubility, blood-brain barrier crossing capability, and ease in tuning photophysical and biological properties have been studied for the AD diagnosis. Herein, we systematically update the progress of NIRF AD probes in the last three years. The special focus is on the mechanisms for the targeted diagnosis and the relationship between the structure and properties of the probes. Importantly, NIRF probes with complementary functions such as dual-responsiveness and multimodal imaging and even therapeutics are discussed. Moreover, the challenges and perspectives of the AD probes are briefly elucidated. We hope that this review provides guidance for researchers and expedites the preclinical and clinical study of the NIRF AD probes.
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
Science and Technology Innovation Commission of Shenzhen["RCBS20200714114910141","JCYJ20210324132816039"] ; General Project of Guangdong Natural Science Foundation[2022A1515011781] ; Guangdong Basic and Applied Basic Research Foundation[2021A1515110086] ; Start-up Grant at Harbin Institute of Technology (Shenzhen)["HA45001108","HA11409049"] ; General Programs of Shenzhen Technical Innovation Committee["JCYJ20210324110004012","JCYJ2019199640","JCYJ20190809110807421"]
WOS Research Area
Chemistry
WOS Subject
Chemistry, Analytical
WOS Accession No
WOS:000863244800001
Publisher
ESI Research Field
CHEMISTRY
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:7
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/405970
DepartmentShenzhen People's Hospital
Affiliation
1.Harbin Inst Technol, Sch Sci, Shenzhen Key Lab Flexible Printed Elect Technol, Shenzhen 518055, Peoples R China
2.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Radiol, Shenzhen 518020, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Geriatr, Shenzhen, Guangdong, Peoples R China
Corresponding Author AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Liu, Yue,Zhuang, Danping,Wang, Jingjing,et al. Recent advances in small molecular near-infrared fluorescence probes for a targeted diagnosis of the Alzheimer disease[J]. ANALYST,2022.
APA
Liu, Yue.,Zhuang, Danping.,Wang, Jingjing.,Huang, Haiyan.,Li, Ruichang.,...&Guo, Bing.(2022).Recent advances in small molecular near-infrared fluorescence probes for a targeted diagnosis of the Alzheimer disease.ANALYST.
MLA
Liu, Yue,et al."Recent advances in small molecular near-infrared fluorescence probes for a targeted diagnosis of the Alzheimer disease".ANALYST (2022).
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