Recent advances in small molecular near-infrared fluorescence probes for a targeted diagnosis of the Alzheimer disease

Liu, Yue1; Zhuang, Danping2,3; Wang, Jingjing1; Huang, Haiyan1; Li, Ruichang1; Wu, Chaoyong1; Deng, Yuanfei4; Hu, Genwen2,3; Guo, Bing1

2022-09-01

10.1039/d2an01327d

ANALYST   Impact Factor & Quartile

0003-2654

1364-5528

Nowadays, it is still quite challenging to achieve an early diagnosis of the Alzheimer disease (AD) in clinics. The burgeoning near-infrared fluorescence (NIRF) imaging fulfills the requirements for a precise diagnosis with good sensitivity and a high signal-to-background ratio and offers opportunities for the efficient AD diagnosis. As the pathogenesis of AD is quite complex, there is an ongoing exploration of advanced probes to specifically target AD biomarkers (e.g., amyloid-beta (A beta) plaques, neurofibrillary tangles, viscosity, peroxynitrite (ONOO-), reactive oxygen species, and methylglyoxal). To this end, a great number of small molecular fluorescent probes with good water solubility, blood-brain barrier crossing capability, and ease in tuning photophysical and biological properties have been studied for the AD diagnosis. Herein, we systematically update the progress of NIRF AD probes in the last three years. The special focus is on the mechanisms for the targeted diagnosis and the relationship between the structure and properties of the probes. Importantly, NIRF probes with complementary functions such as dual-responsiveness and multimodal imaging and even therapeutics are discussed. Moreover, the challenges and perspectives of the AD probes are briefly elucidated. We hope that this review provides guidance for researchers and expedites the preclinical and clinical study of the NIRF AD probes.

SCI

English

Corresponding

Science and Technology Innovation Commission of Shenzhen["RCBS20200714114910141","JCYJ20210324132816039"] ; General Project of Guangdong Natural Science Foundation[2022A1515011781] ; Guangdong Basic and Applied Basic Research Foundation[2021A1515110086] ; Start-up Grant at Harbin Institute of Technology (Shenzhen)["HA45001108","HA11409049"] ; General Programs of Shenzhen Technical Innovation Committee["JCYJ20210324110004012","JCYJ2019199640","JCYJ20190809110807421"]

Chemistry

Chemistry, Analytical

WOS:000863244800001

ROYAL SOC CHEMISTRY

CHEMISTRY

Web of Science

1.Harbin Inst Technol, Sch Sci, Shenzhen Key Lab Flexible Printed Elect Technol, Shenzhen 518055, Peoples R China
2.Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Dept Radiol, Shenzhen 518020, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
4.Peking Univ, Shenzhen Hosp, Dept Geriatr, Shenzhen, Guangdong, Peoples R China

Liu, Yue,Zhuang, Danping,Wang, Jingjing,et al. Recent advances in small molecular near-infrared fluorescence probes for a targeted diagnosis of the Alzheimer disease[J]. ANALYST,2022.

Liu, Yue.,Zhuang, Danping.,Wang, Jingjing.,Huang, Haiyan.,Li, Ruichang.,...&Guo, Bing.(2022).Recent advances in small molecular near-infrared fluorescence probes for a targeted diagnosis of the Alzheimer disease.ANALYST.

Liu, Yue,et al."Recent advances in small molecular near-infrared fluorescence probes for a targeted diagnosis of the Alzheimer disease".ANALYST (2022).