| Title | Recent Advances in the Enzyme-Activatable Organic Fluorescent Probes for Tumor Imaging and Therapy |
| Author | |
| Corresponding Author | Li, Kai |
| Publication Years | 2022-10-01
|
| DOI | |
| Source Title | |
| ISSN | 2191-1363
|
| Volume | 11Issue:10 |
| Abstract | The exploration of advanced probes for cancer diagnosis and treatment is of high importance in fundamental research and clinical practice. In comparison with the traditional "always-on" probes, the emerging activatable probes enjoy advantages in promoted accuracy for tumor theranostics by specifically releasing or activating fluorophores at the targeting sites. The main designing principle for these probes is to incorporate responsive groups that can specifically react with the biomarkers (e. g., enzymes) involved in tumorigenesis and progression, realizing the controlled activation in tumors. In this review, we summarize the latest advances in the molecular design and biomedical application of enzyme-responsive organic fluorescent probes. Particularly, the fluorophores can be endowed with ability of generating reactive oxygen species (ROS) to afford the photosensitizers, highlighting the potential of these probes in simultaneous tumor imaging and therapy with rational design. We hope that this review could inspire more research interests in the development of tumor-targeting theranostic probes for advanced biological studies. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | Ministry of Science and Technology of China[2020YFA0908900]
; National Natural Science Foundation of China["U21 A2097","31870991"]
; Department of Science and Technology of Guangdong Province["2022B1212010003","2019ZT08Y191","2019QN01Y640"]
; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009]
; Shenzhen Science and Technology Program["JSGG20200225151916021","KQTD20190929172743294"]
|
| WOS Research Area | Chemistry
|
| WOS Subject | Chemistry, Multidisciplinary
|
| WOS Accession No | WOS:000864161900001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/405989 |
| Department | Department of Biomedical Engineering |
| Affiliation | Southern Univ Sci & Technol SUSTech, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen Key Lab Smart Healthcare Engn, Shenzhen 518055, Peoples R China |
| First Author Affilication | Department of Biomedical Engineering |
| Corresponding Author Affilication | Department of Biomedical Engineering |
| First Author's First Affilication | Department of Biomedical Engineering |
| Recommended Citation GB/T 7714 |
Lu, Song-Bo,Wei, Luyao,He, Wenjing,et al. Recent Advances in the Enzyme-Activatable Organic Fluorescent Probes for Tumor Imaging and Therapy[J]. ChemistryOpen,2022,11(10).
|
| APA |
Lu, Song-Bo.,Wei, Luyao.,He, Wenjing.,Bi, Zhen-Yu.,Qian, Yuhan.,...&Li, Kai.(2022).Recent Advances in the Enzyme-Activatable Organic Fluorescent Probes for Tumor Imaging and Therapy.ChemistryOpen,11(10).
|
| MLA |
Lu, Song-Bo,et al."Recent Advances in the Enzyme-Activatable Organic Fluorescent Probes for Tumor Imaging and Therapy".ChemistryOpen 11.10(2022).
|
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