Gene editing monkeys: Retrospect and outlook

Liang, Weizheng1; He, Junli2; Mao, Chenyu3; Yu, Chengwei4; Meng, Qingxue1; Xue, Jun5; Wu, Xueliang5; Li, Shanliang6; Wang, Yukai7,8,9,10; Yi, Hongyang11,12

2022-09-08

10.3389/fcell.2022.913996

Frontiers in Cell and Developmental Biology   Impact Factor & Quartile

2296-634X

Animal models play a key role in life science research, especially in the study of human disease pathogenesis and drug screening. Because of the closer proximity to humans in terms of genetic evolution, physiology, immunology, biochemistry, and pathology, nonhuman primates (NHPs) have outstanding advantages in model construction for disease mechanism study and drug development. In terms of animal model construction, gene editing technology has been widely applied to this area in recent years. This review summarizes the current progress in the establishment of NHPs using gene editing technology, which mainly focuses on rhesus and cynomolgus monkeys. In addition, we discuss the limiting factors in the applications of genetically modified NHP models as well as the possible solutions and improvements. Furthermore, we highlight the prospects and challenges of the gene-edited NHP models.

nonhuman primates gene editing rhesus monkeys cynomolgus monkeys CRISPR Cas9 human diseases

SCI

English

Corresponding

Cell Biology ; Developmental Biology

Cell Biology ; Developmental Biology

WOS:000859972900001

FRONTIERS MEDIA SA

Web of Science

1.Hebei North Univ, Cent Lab, Affiliated Hosp 1, Zhangjiakou, Peoples R China
2.Shenzhen Univ, Dept Pediat, Gen Hosp, Shenzhen, Peoples R China
3.Univ Penn, Philadelphia, PA 19104 USA
4.Univ Chinese Acad Sci, Sch Future Technol, Beijing, Peoples R China
5.Hebei North Univ, Dept Gen Surg, Affiliated Hosp 1, Zhangjiakou, Peoples R China
6.Guangxi Univ Chinese Med, Dept Pharmacol, Nanning, Peoples R China
7.Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing, Peoples R China
8.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing, Peoples R China
9.Beijing Inst Stem Cell & Regenerat Med, Beijing, Peoples R China
10.Chinese Acad Sci, Natl Stem Cell Resource Ctr, Beijing, Peoples R China
11.Third Peoples Hosp Shenzhen, Natl Clin Res Ctr Infect Dis, Shenzhen, Peoples R China
12.Southern Univ Sci & Technol, Affiliated Hosp 2, Shenzhen, Peoples R China

Liang, Weizheng,He, Junli,Mao, Chenyu,et al. Gene editing monkeys: Retrospect and outlook[J]. Frontiers in Cell and Developmental Biology,2022,10.

Liang, Weizheng.,He, Junli.,Mao, Chenyu.,Yu, Chengwei.,Meng, Qingxue.,...&Yi, Hongyang.(2022).Gene editing monkeys: Retrospect and outlook.Frontiers in Cell and Developmental Biology,10.

Liang, Weizheng,et al."Gene editing monkeys: Retrospect and outlook".Frontiers in Cell and Developmental Biology 10(2022).