| Title | Visible-light-induced radical cascade reaction to prepare oxindoles via alkyl radical addition to N-arylacryl amides |
| Author | |
| Corresponding Author | Che, Chi-Ming |
| Publication Years | 2022-09-01
|
| DOI | |
| Source Title | |
| ISSN | 2052-4129
|
| Abstract | Herein we describe a photochemical approach towards oxindoles by the radical cascade reaction of alpha,beta-unsaturated N-arylacryl amides with alkyl bromides or iodides upon visible light irradiation. This transition metal- and photosensitizer-free protocol afforded diverse oxindoles with C3 quaternary centers in high product yields under mild reaction conditions. Importantly, the method was applicable to prepare the core skeletons of (+/-)-physovenine, (+/-)-esermethole and (+/-)-physostigmine. |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | Guangdong Major Project of Basic and Applied Basic Research[2019B030302009]
; Shenzhen Science and Technology Innovation Commission[JCYJ20180508162429786]
|
| WOS Research Area | Chemistry
|
| WOS Subject | Chemistry, Organic
|
| WOS Accession No | WOS:000858922200001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:3
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/406045 |
| Department | Department of Chemistry |
| Affiliation | 1.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China 2.Univ Hong Kong, Dept Chem, State Key Lab Synthet Chem, Pokfulam Rd, Hong Kong, Peoples R China 3.HKU Shenzhen Inst Res & Innovat, Shenzhen 518057, Guangdong, Peoples R China 4.Lab Synthet Chem & Chem Biol Ltd, Units 1503-1511,15-F,Bldg 17W,Hong Kong Sci Pk, Hong Kong, Peoples R China |
| First Author Affilication | Department of Chemistry |
| Corresponding Author Affilication | Department of Chemistry |
| First Author's First Affilication | Department of Chemistry |
| Recommended Citation GB/T 7714 |
Cheng, Hanchao,Luo, Yunfeng,Lam, Tsz-Lung,et al. Visible-light-induced radical cascade reaction to prepare oxindoles via alkyl radical addition to N-arylacryl amides[J]. Organic Chemistry Frontiers,2022.
|
| APA |
Cheng, Hanchao,Luo, Yunfeng,Lam, Tsz-Lung,Liu, Yungen,&Che, Chi-Ming.(2022).Visible-light-induced radical cascade reaction to prepare oxindoles via alkyl radical addition to N-arylacryl amides.Organic Chemistry Frontiers.
|
| MLA |
Cheng, Hanchao,et al."Visible-light-induced radical cascade reaction to prepare oxindoles via alkyl radical addition to N-arylacryl amides".Organic Chemistry Frontiers (2022).
|
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