Association of healthy lifestyles on the risk of hypertension, type 2 diabetes mellitus, and their comorbidity among subjects with dyslipidemia

Hu，Peng1,2; Zheng，Murui3; Duan，Xueru2; Zhou，Huanning4; Huang，Jun5; Lao，Lixian6; Zhao，Yue2; Li，Yi2; Xue，Meng2; Zhao，Wenjing7; Deng，Hai6; Liu，Xudong1

2022-09-26

10.3389/fnut.2022.1006379

Frontiers in Nutrition   Impact Factor & Quartile

2296-861X

2296-861X

Background: Adherence to a healthy lifestyle could reduce the risk of hypertension and diabetes in general populations; however, whether the associations exist in subjects with dyslipidemia remains unclear. This study aimed to investigate the integrated effect of lifestyle factors on the risk of hypertension, type 2 diabetes mellitus (T2DM), and their comorbidity among subjects with dyslipidemia. Methods: In total of 9,339 subjects with dyslipidemia were recruited from the baseline survey of the Guangzhou Heart Study. A questionnaire survey and medical examination were performed. The healthy lifestyle score (HLS) was derived from five factors: smoking, alcohol drinking, diet, body mass index, and leisure-time physical activity. Odds ratios (ORs) with 95% confidence interval (95% CI) were calculated by using the logistic regression model and the multinomial logistic regression after adjusting for confounders. Results: The prevalence of hypertension, T2DM, and their comorbidity was 47.65, 16.02, and 10.10%, respectively. Subjects with a higher HLS were associated with a lower risk of hypertension, T2DM, and their comorbidity. In comparison to the subjects with 0–2 HLS, the adjusted ORs for subjects with five HLS was 0.48 (95% CI: 0.40–0.57) and 0.67 (95% CI: 0.54–0.84) for hypertension and T2DM. Compared with subjects with 0-2 HLS and neither hypertension nor T2DM, those with five HLS had a lower risk of suffering from only one disease (OR: 0.48, 95% CI: 0.40–0.57) and their comorbidity (OR: 0.35, 95% CI: 0.26–0.47). Conclusions: The results suggest that the more kinds of healthy lifestyle, the lower the risk of hypertension, T2DM, and their comorbidity among subjects with dyslipidemia. Preventive strategies incorporating lifestyle factors may provide a more feasible approach for the prevention of main chronic diseases.

comorbidity diabetes hypertension lifestyle subjects with dyslipidemia

SCI

English

Corresponding

Guangdong Basic and Applied Basic Research Foundation[202102080404] ; the Guangdong Provincial Key RD Program[2022A1515010686] ; National Key R&D Program of China[2019B020230004] ; [2018YFC1312502]

Nutrition & Dietetics

Nutrition & Dietetics

WOS:000874027600001

FRONTIERS MEDIA SA

2-s2.0-85139496928

Scopus

1.School of Public Health,Guangdong Pharmaceutical University,Guangzhou,China
2.Department of Epidemiology,School of Public Health,Sun Yat-sen University,Guangzhou,China
3.Department of Community Health,Guangzhou Center for Disease Control and Prevention,Guangzhou,China
4.Department of Chronic Disease,Guangzhou Yuexiu District Center for Disease Control and Prevention,Guangzhou,China
5.Department of Geriatrics,Institute of Geriatrics,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Science,Guangzhou,China
6.Department of Cardiology,Guangdong Cardiovascular Institute,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Science,Guangzhou,China
7.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,China

Hu，Peng,Zheng，Murui,Duan，Xueru,et al. Association of healthy lifestyles on the risk of hypertension, type 2 diabetes mellitus, and their comorbidity among subjects with dyslipidemia[J]. Frontiers in Nutrition,2022,9.

Hu，Peng.,Zheng，Murui.,Duan，Xueru.,Zhou，Huanning.,Huang，Jun.,...&Liu，Xudong.(2022).Association of healthy lifestyles on the risk of hypertension, type 2 diabetes mellitus, and their comorbidity among subjects with dyslipidemia.Frontiers in Nutrition,9.

Hu，Peng,et al."Association of healthy lifestyles on the risk of hypertension, type 2 diabetes mellitus, and their comorbidity among subjects with dyslipidemia".Frontiers in Nutrition 9(2022).