Selective dehydrogenation of small and large molecules by a chloroiridium catalyst

Wang，Kuan1; Gan，Lan1,2; Wu，Yuheng1; Zhou，Min Jie1,3; Liu，Guixia1; Huang，Zheng1,2

2022-09-23

10.1126/sciadv.abo6586

Science Advances   Impact Factor & Quartile

2375-2548

2375-2548

The dehydrogenation of abundant alkane feedstocks to olefins is one of the mostly intensively investigated reactions in organic catalysis. A long-standing, pervasive challenge in this transformation is the direct dehydrogenation of unactivated 1,1-disubstituted ethane, an aliphatic motif commonly found in organic molecules. Here, we report the design of a diphosphine chloroiridium catalyst for undirected dehydrogenation of this aliphatic class to form valuable 1,1-disubstituted ethylene. Featuring high site selectivity and excellent functional group compatibility, this catalytic system is applicable to late-stage dehydrogenation of complex bioactive molecules. Moreover, the system enables unprecedented dehydrogenation of polypropene with controllable degree of desaturation, dehydrogenating more than 10 in 100 propene units. Further derivatizations of the resulting double bonds afford functionalized polypropenes.

SCI

English

NI Journal Papers

Others

National Key R&D Program of China["2021YFA1501700","2021YFA1500100"] ; National Natural Science Foundation of China["21825109","22072178","21821002","21732006"]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000885315600013

AMER ASSOC ADVANCEMENT SCIENCE

2-s2.0-85139303783

Scopus

1.State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai,200032,China
2.School of Chemistry and Material Sciences,Hangzhou Institute of Advanced Study,Hangzhou,310024,China
3.Shenzhen Grubbs Institute and Department of Chemistry,Southern University of Science and Technology,Shenzhen,518055,China

Wang，Kuan,Gan，Lan,Wu，Yuheng,et al. Selective dehydrogenation of small and large molecules by a chloroiridium catalyst[J]. Science Advances,2022,8(38).

Wang，Kuan,Gan，Lan,Wu，Yuheng,Zhou，Min Jie,Liu，Guixia,&Huang，Zheng.(2022).Selective dehydrogenation of small and large molecules by a chloroiridium catalyst.Science Advances,8(38).

Wang，Kuan,et al."Selective dehydrogenation of small and large molecules by a chloroiridium catalyst".Science Advances 8.38(2022).