中文版 | English
Title

Near-Infrared Optical Transducer for Dynamic Imaging of Cerebrospinal Fluid Glucose in Brain Tumor

Author
Corresponding AuthorWu,Changfeng
Publication Years
2022
DOI
Source Title
ISSN
0003-2700
EISSN
1520-6882
Abstract
Aberrant cerebral glucose metabolism is related to many brain diseases, especially brain tumor. However, it remains challenging to measure the dynamic changes in cerebral glucose. Here, we developed a near-infrared (NIR) optical transducer to sensitively monitor the glucose variations in cerebrospinal fluid in vivo. The transducer consists of an oxygen-sensitive nanoparticle combined with glucose oxidase (GOx), yielding highly sensitive NIR phosphorescence in response to blood glucose change. We demonstrated long-term continuous glucose monitoring by using the NIR transducer. After subcutaneous implantation, the glucose transducer provides a strong luminescence signal that can continuously monitor blood glucose fluctuations for weeks. By using the NIR emission of the transducer, we further observed abnormal dynamic changes in cerebrospinal fluid glucose and quantitatively assessed cerebral glucose uptake rates in transgenic mice bearing brain tumors. This study provides a promising method for the diagnosis of various metabolic diseases with altered glucose metabolism.
URL[Source Record]
Indexed By
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
Corresponding
Funding Project
National Key R&D Program of China[2020YFA0909000] ; Shenzhen Science and Technology Program["KQTD20170810111314625","JCYJ20210324115807021"] ; Shenzhen Bay Laboratory[SZBL2021080601002]
WOS Research Area
Chemistry
WOS Subject
Chemistry, Analytical
WOS Accession No
WOS:000875681300001
Publisher
ESI Research Field
CHEMISTRY
Scopus EID
2-s2.0-85139520917
Data Source
Scopus
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/406225
DepartmentDepartment of Biomedical Engineering
Affiliation
1.Harbin Institute of Technology,Harbin,150001,China
2.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
3.Department of Chemistry and Bioengineering,University of Washington,Seattle,4000 15th NE,98195,United States
First Author AffilicationDepartment of Biomedical Engineering
Corresponding Author AffilicationDepartment of Biomedical Engineering
Recommended Citation
GB/T 7714
Liu,Siyang,Liu,Ye,Zhang,Zhe,et al. Near-Infrared Optical Transducer for Dynamic Imaging of Cerebrospinal Fluid Glucose in Brain Tumor[J]. ANALYTICAL CHEMISTRY,2022.
APA
Liu,Siyang.,Liu,Ye.,Zhang,Zhe.,Wang,Xiaodong.,Yang,Yicheng.,...&Wu,Changfeng.(2022).Near-Infrared Optical Transducer for Dynamic Imaging of Cerebrospinal Fluid Glucose in Brain Tumor.ANALYTICAL CHEMISTRY.
MLA
Liu,Siyang,et al."Near-Infrared Optical Transducer for Dynamic Imaging of Cerebrospinal Fluid Glucose in Brain Tumor".ANALYTICAL CHEMISTRY (2022).
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