A Freshwater Fish-Based Diet Alleviates Liver Steatosis by Modulating Gut Microbiota and Metabolites: A Clinical Randomized Controlled Trial in Chinese Participants With Nonalcoholic Fatty Liver Disease

He Kaiyin1; Guo Li-Liangzi1,2; Tang Huijun1,3; Peng Xiaojuan4; Li Juan1,5; Feng Shufen1; Bie Caiqun3; Chen Weiwei1; Li Yuting1; Wang Min1; Tang Shaohui1

2022-10-01

10.14309/ajg.0000000000001885

AMERICAN JOURNAL OF GASTROENTEROLOGY   Impact Factor & Quartile

0002-9270

1572-0241

INTRODUCTION:We aimed to assess the effects of 2 isoenergetic intervention diets (a freshwater fish-based diet [F group] or freshwater fish-based and red meat-based diets alternately [F/M group]) on liver steatosis and their relationship with intestinal flora in patients with nonalcoholic fatty liver disease (NAFLD). METHODS:In this open-label, 84-day randomized controlled trial, 34 NAFLD patients with hepatic steatosis >= 10% were randomly assigned to the F group or F/M group in a 1:1 ratio using a computer-generated random number allocation by a researcher not involved in the study. Liver fat content and gut microbiota and its metabolites were measured. RESULTS:At the end of intervention, the absolute reduction of hepatic steatosis was significantly greater in the F group than in the F/M group (-4.89% vs -1.83%, P = 0.032). Of the 16 secondary clinical outcomes, the improvement in 7 in the F group was greater compared with the F/M group, including alanine aminotransferase and gamma-glutamyl transferase. Furthermore, dietary freshwater fish and red meat consumption alternately did not exacerbate NAFLD. Moreover, changes in the enrichment of Faecalibacterium, short-chain fatty acids, and unconjugated bile acids and the depletion of Prevotella 9 and conjugated bile acids in the F group were significantly greater compared with the F/M group. DISCUSSION:Higher intake of freshwater fish may be beneficial to NAFLD by regulating gut microbiota and its metabolites, whereas intake of a similar total of animal protein and fat from the alternating freshwater fish and red meat may not be harmful for NAFLD in the dietary management of patients with NAFLD.

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English

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Natural Science Foundation of Hunan Province, China[2021JJ70048] ; Health Commission Funding Project of Hunan Province, China[B2019145] ; Science and Technology Funding Project of Bao'an District of Shenzhen, Guangdong Province, China[2020JD293] ; Minsheng Science and Technology Funding Project of Liaoning Province, China[2021JH2/10300046] ; Medical Science and Technology Foundation of Guangdong Province["A2018011","C2020076"]

Gastroenterology & Hepatology

Gastroenterology & Hepatology

WOS:000863739000019

LIPPINCOTT WILLIAMS & WILKINS

CLINICAL MEDICINE

Web of Science

1.Jinan Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou, Peoples R China
2.Jinan Univ, Southern Univ Sci & Technol,Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2, Dept Gastroenterol, Shenzhen, Peoples R China
3.Shenzhen Hosp Integrated Tradit Chinese & w Med, Dept Gastroenterol, Shenzhen, Peoples R China
4.Liuzhou Peoples Hosp, Dept Endocrinol, Liuzhou, Peoples R China
5.Jinzhou Med Univ, Affiliated Hosp 3, Dept Gastroenterol, Jinzhou, Peoples R China

He Kaiyin,Guo Li-Liangzi,Tang Huijun,et al. A Freshwater Fish-Based Diet Alleviates Liver Steatosis by Modulating Gut Microbiota and Metabolites: A Clinical Randomized Controlled Trial in Chinese Participants With Nonalcoholic Fatty Liver Disease[J]. AMERICAN JOURNAL OF GASTROENTEROLOGY,2022,117(10).

He Kaiyin.,Guo Li-Liangzi.,Tang Huijun.,Peng Xiaojuan.,Li Juan.,...&Tang Shaohui.(2022).A Freshwater Fish-Based Diet Alleviates Liver Steatosis by Modulating Gut Microbiota and Metabolites: A Clinical Randomized Controlled Trial in Chinese Participants With Nonalcoholic Fatty Liver Disease.AMERICAN JOURNAL OF GASTROENTEROLOGY,117(10).

He Kaiyin,et al."A Freshwater Fish-Based Diet Alleviates Liver Steatosis by Modulating Gut Microbiota and Metabolites: A Clinical Randomized Controlled Trial in Chinese Participants With Nonalcoholic Fatty Liver Disease".AMERICAN JOURNAL OF GASTROENTEROLOGY 117.10(2022).