中文版 | English
Title

Luteolin Inhibited the Self-Renewal and Altered the Polarization of Primary Alveolar Macrophages

Author
Corresponding AuthorGong, Daoyin
Publication Years
2022-08-18
DOI
Source Title
ISSN
1555-4309
EISSN
1555-4317
Volume2022
Abstract
Pure plant extract luteolin has been demonstrated to possess numerous biological and immunological effects. However, how luteolin affects mice alveolar macrophages' self-renewal and polarization closely related to inflammatory and immunomodulatory is still unknown. In our study, the transcriptomic analysis showed that several self-renewal-related pathways in luteolin-pretreated alveolar macrophages were inhibited compared to the granulocyte-macrophage colony-stimulating factor (GM-CSF)-treated group. Ki-67 staining and EdU assay indicated that luteolin inhibited GM-CSF-induced alveolar macrophage proliferation. Moreover, GM-CSF-induced expressions of c-Myc and KLF4 were significantly suppressed by luteolin at transcriptional and protein levels. Besides, we found that luteolin promoted M1 macrophage polarization induced by LPS plus IFN-gamma. At the same time, it inhibited M2 macrophage polarization induced by IL-4 in both alveolar and bone marrow-derived macrophages by detecting macrophage polarization-related gene expressions at mRNA and protein levels. We found that luteolin inhibited self-renewal and altered the polarization of primary alveolar macrophages. Taken together, our data will aid in a better understanding of the immunomodulatory effects of luteolin on the primary alveolar macrophages.
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
Funding Project
General project of National Natural Science Foundation of China[8187142249]
WOS Research Area
Radiology, Nuclear Medicine & Medical Imaging
WOS Subject
Radiology, Nuclear Medicine & Medical Imaging
WOS Accession No
WOS:000867389600002
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/406535
DepartmentShenzhen People's Hospital
Affiliation
1.Chengdu Univ Tradit Chinese Med, Sch Basic Med Sci, Chengdu 611137, Peoples R China
2.Shanxi Univ Tradit Chinese Med, Affiliated Hosp, Taiyuan 030024, Peoples R China
3.Southern Univ Sci & Technol, Inst Resp Dis, Affiliated Hosp 1, Shenzhen Peoples Hosp, Shenzhen 518020, Peoples R China
4.Hosp Chengdu Univ Tradit Chinese Med, Chengdu 610075, Peoples R China
Recommended Citation
GB/T 7714
Geng, Aiai,Chen, Shanze,Ren, Laibin,et al. Luteolin Inhibited the Self-Renewal and Altered the Polarization of Primary Alveolar Macrophages[J]. Contrast Media & Molecular Imaging,2022,2022.
APA
Geng, Aiai.,Chen, Shanze.,Ren, Laibin.,Zhao, Xueyi.,Pei, Tianli.,...&Gong, Daoyin.(2022).Luteolin Inhibited the Self-Renewal and Altered the Polarization of Primary Alveolar Macrophages.Contrast Media & Molecular Imaging,2022.
MLA
Geng, Aiai,et al."Luteolin Inhibited the Self-Renewal and Altered the Polarization of Primary Alveolar Macrophages".Contrast Media & Molecular Imaging 2022(2022).
Files in This Item:
There are no files associated with this item.
Related Services
Fulltext link
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Export to Excel
Export to Csv
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Geng, Aiai]'s Articles
[Chen, Shanze]'s Articles
[Ren, Laibin]'s Articles
Baidu Scholar
Similar articles in Baidu Scholar
[Geng, Aiai]'s Articles
[Chen, Shanze]'s Articles
[Ren, Laibin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Geng, Aiai]'s Articles
[Chen, Shanze]'s Articles
[Ren, Laibin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.