Title | Luteolin Inhibited the Self-Renewal and Altered the Polarization of Primary Alveolar Macrophages |
Author | |
Corresponding Author | Gong, Daoyin |
Publication Years | 2022-08-18
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DOI | |
Source Title | |
ISSN | 1555-4309
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EISSN | 1555-4317
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Volume | 2022 |
Abstract | Pure plant extract luteolin has been demonstrated to possess numerous biological and immunological effects. However, how luteolin affects mice alveolar macrophages' self-renewal and polarization closely related to inflammatory and immunomodulatory is still unknown. In our study, the transcriptomic analysis showed that several self-renewal-related pathways in luteolin-pretreated alveolar macrophages were inhibited compared to the granulocyte-macrophage colony-stimulating factor (GM-CSF)-treated group. Ki-67 staining and EdU assay indicated that luteolin inhibited GM-CSF-induced alveolar macrophage proliferation. Moreover, GM-CSF-induced expressions of c-Myc and KLF4 were significantly suppressed by luteolin at transcriptional and protein levels. Besides, we found that luteolin promoted M1 macrophage polarization induced by LPS plus IFN-gamma. At the same time, it inhibited M2 macrophage polarization induced by IL-4 in both alveolar and bone marrow-derived macrophages by detecting macrophage polarization-related gene expressions at mRNA and protein levels. We found that luteolin inhibited self-renewal and altered the polarization of primary alveolar macrophages. Taken together, our data will aid in a better understanding of the immunomodulatory effects of luteolin on the primary alveolar macrophages. |
URL | [Source Record] |
Indexed By | |
Language | English
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SUSTech Authorship | Others
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Funding Project | General project of National Natural Science Foundation of China[8187142249]
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WOS Research Area | Radiology, Nuclear Medicine & Medical Imaging
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WOS Subject | Radiology, Nuclear Medicine & Medical Imaging
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WOS Accession No | WOS:000867389600002
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Publisher | |
Data Source | Web of Science
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Citation statistics |
Cited Times [WOS]:0
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/406535 |
Department | Shenzhen People's Hospital |
Affiliation | 1.Chengdu Univ Tradit Chinese Med, Sch Basic Med Sci, Chengdu 611137, Peoples R China 2.Shanxi Univ Tradit Chinese Med, Affiliated Hosp, Taiyuan 030024, Peoples R China 3.Southern Univ Sci & Technol, Inst Resp Dis, Affiliated Hosp 1, Shenzhen Peoples Hosp, Shenzhen 518020, Peoples R China 4.Hosp Chengdu Univ Tradit Chinese Med, Chengdu 610075, Peoples R China |
Recommended Citation GB/T 7714 |
Geng, Aiai,Chen, Shanze,Ren, Laibin,et al. Luteolin Inhibited the Self-Renewal and Altered the Polarization of Primary Alveolar Macrophages[J]. Contrast Media & Molecular Imaging,2022,2022.
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APA |
Geng, Aiai.,Chen, Shanze.,Ren, Laibin.,Zhao, Xueyi.,Pei, Tianli.,...&Gong, Daoyin.(2022).Luteolin Inhibited the Self-Renewal and Altered the Polarization of Primary Alveolar Macrophages.Contrast Media & Molecular Imaging,2022.
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MLA |
Geng, Aiai,et al."Luteolin Inhibited the Self-Renewal and Altered the Polarization of Primary Alveolar Macrophages".Contrast Media & Molecular Imaging 2022(2022).
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