Novel lipid indicators and the risk of type 2 diabetes mellitus among Chinese hypertensive patients: findings from the Guangzhou Heart Study

Deng，Hai1; Hu，Peng2,3; Li，Huoxing4; Zhou，Huanning5; Wu，Xiuyi6; Yuan，Maohua7; Duan，Xueru3; Lao，Miaochao8; Wu，Chuchu2; Zheng，Murui9; Lao，Xiang Qian10; Zhao，Wenjing11; Liu，Xudong2

2022-12-01

10.1186/s12933-022-01660-z

Cardiovascular Diabetology   Impact Factor & Quartile

1475-2840

Background: Data are limited on whether several easily measured indices are independent predictors of type 2 diabetes mellitus (T2DM) in hypertensive patients. This study aimed to assess the association of hypertriglyceridemic-waist phenotype, triglyceride glucose (TyG) index, lipid accumulation product (LAP), and visceral adiposity index (VAI) with T2DM risk in hypertensive patients. Methods: This cross-sectional study included 5321 hypertensive patients from the baseline survey of the Guangzhou Heart Study. Face-to-face questionnaire survey, physical examination, and fasting blood sample collection were completed for all subjects. Odds ratio (OR) with 95% confidence interval (95% CI) were calculated by using the logistic regression model. The potential nonlinear relationship was examined using restricted cubic spline regression. Results: The prevalence of T2DM was 19.98% among hypertensive patients. After adjusting for confounders, participants with elevated triglyceride levels and enlarged waist circumference (HTGW) were associated with a 2.57-fold risk of T2DM (OR 2.57, 95% CI 2.05, 3.23). When comparing with subjects within the lowest quartile of the indices, those in the highest quartile of TyG, LAP, and VAI were associated with 5.35-fold (95% CI 4.33, 6.64), 2.65-fold (95% CI 2.11, 3.34), and 2.17-fold (95% CI 1.77, 2.67) risk of T2DM after adjusting for confounders. Every 1-unit increment of TyG, LAP, and VAI was associated with 81%, 38%, and 31% increased risk of T2DM, respectively. The nonlinear association was observed for TyG, LAP, and VAI (all P < 0.001). Conclusions: The results found that among hypertensive patients, HTGW and a higher level of TyG, LAP, and VAI were associated with an elevated risk of T2DM. The findings suggested that HTGW, TyG, LAP, and VAI may serve as simple and effective tools for T2DM risk assessment in the prevention and management of main chronic diseases.

Diabetes Hypertension Hypertriglyceridemic-waist phenotype Lipid accumulation product Triglyceride glucose index Visceral adiposity index

SCI

English

Corresponding

Science and Technology Program of Guangzhou City[202102080404] ; Guangdong Basic and Applied Basic Research Foundation[2022A1515010686] ; Guangdong Provincial Key RD Program[2019B020230004] ; National Key R&D Program of China[2018YFC1312502]

Cardiovascular System & Cardiology ; Endocrinology & Metabolism

Cardiac & Cardiovascular Systems ; Endocrinology & Metabolism

WOS:000868384900002

BMC

2-s2.0-85139888661

Scopus

1.Department of Cardiology,Guangdong Cardiovascular Institute,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Science,Guangzhou,510080,China
2.School of Public Health,Guangdong Pharmaceutical University,Guangzhou,No. 283 Jianghai Avenue, Haizhu District,510310,China
3.Department of Epidemiology,School of Public Health,Sun Yat-Sen University,Guangzhou,510080,China
4.The Second School of Clinical Medicine,Southern Medical University,Guangzhou,510515,China
5.Guangzhou Yuexiu District Center for Disease Control and Prevention,Guangzhou,China
6.Nancun Community Health Service Center,Guangzhou,511442,China
7.Dadong Street Community Health Service Center,Guangzhou,510080,China
8.Department of Sleep Center,Department of Geriatric Respiratory,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangdong Provincial Geriatrics Institute,Guangzhou,510080,China
9.Department of Community Health,Guangzhou Center for Disease Control and Prevention,Guangzhou,No. 1 Qide Road, Baiyun District,510440,China
10.JC School of Public Health and Primary Care,Faculty of Medicine,The Chinese University of Hong Kong,SAR,999077,Hong Kong
11.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,No. 1088 Xueyuan Avenue,518055,China

Deng，Hai,Hu，Peng,Li，Huoxing,et al. Novel lipid indicators and the risk of type 2 diabetes mellitus among Chinese hypertensive patients: findings from the Guangzhou Heart Study[J]. Cardiovascular Diabetology,2022,21(1).

Deng，Hai.,Hu，Peng.,Li，Huoxing.,Zhou，Huanning.,Wu，Xiuyi.,...&Liu，Xudong.(2022).Novel lipid indicators and the risk of type 2 diabetes mellitus among Chinese hypertensive patients: findings from the Guangzhou Heart Study.Cardiovascular Diabetology,21(1).

Deng，Hai,et al."Novel lipid indicators and the risk of type 2 diabetes mellitus among Chinese hypertensive patients: findings from the Guangzhou Heart Study".Cardiovascular Diabetology 21.1(2022).