Title | A protein synthesis brake for hematopoietic stem cell maintenance |
Author | |
Publication Years | 2022-08-01
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DOI | |
Source Title | |
ISSN | 0890-9369
|
EISSN | 1549-5477
|
Volume | 36Issue:15-16Pages:871-873 |
Abstract | Bmi1 is essential for normal and leukemic hematopoiesis, but its target genes in hematopoietic stem cells (HSCs) are incompletely understood. In this issue of Genes & Development, Burgess et al. (pp. 887-900) demonstrate a novel role of Bmi1 in regulating ribosome biogenesis and protein synthesis. Bmi1-deficient HSCs exhibited reduced transplantability, with the up-regulation of ARX and genes involved in ribosome biogenesis. However, depletion of ARX or its known targets, p16Ink4a/p19Arf , only partially rescues Bmi1 loss-induced hematopoietic defects. They further demonstrate an increased protein synthesis rate and resultant proteostatic stress in Bmi1-/- HSCs, indicating a novel mechanism by which Bmi1 controls HSC maintenance. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
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Important Publications | NI Journal Papers
|
SUSTech Authorship | First
|
Funding Project | Southern University of Science and Technology[Y011286101]
; National Institutes of Health["R01DK127738","R01CA271523"]
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WOS Research Area | Cell Biology
; Developmental Biology
; Genetics & Heredity
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WOS Subject | Cell Biology
; Developmental Biology
; Genetics & Heredity
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WOS Accession No | WOS:000870849800001
|
Publisher | |
Scopus EID | 2-s2.0-85139571024
|
Data Source | Scopus
|
Citation statistics |
Cited Times [WOS]:0
|
Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/406589 |
Department | Department of Biochemistry 南方科技大学医学院 |
Affiliation | 1.Department of Biochemistry,School of Medicine,Southern University of Science and Technology,Shenzhen,518000,China 2.Children's Hospital of Philadelphia; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA |
First Author Affilication | Department of Biochemistry; School of Medicine |
First Author's First Affilication | Department of Biochemistry; School of Medicine |
Recommended Citation GB/T 7714 |
Lv,Kaosheng,Tong,Wei. A protein synthesis brake for hematopoietic stem cell maintenance[J]. Genes & development,2022,36(15-16):871-873.
|
APA |
Lv,Kaosheng,&Tong,Wei.(2022).A protein synthesis brake for hematopoietic stem cell maintenance.Genes & development,36(15-16),871-873.
|
MLA |
Lv,Kaosheng,et al."A protein synthesis brake for hematopoietic stem cell maintenance".Genes & development 36.15-16(2022):871-873.
|
Files in This Item: | ||||||
File Name/Size | DocType | Version | Access | License | ||
Genes Dev.-2022-Lv-8(519KB) | Open Access | -- | View |
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