中文版 | English
Title

A protein synthesis brake for hematopoietic stem cell maintenance

Author
Publication Years
2022-08-01
DOI
Source Title
ISSN
0890-9369
EISSN
1549-5477
Volume36Issue:15-16Pages:871-873
Abstract

Bmi1 is essential for normal and leukemic hematopoiesis, but its target genes in hematopoietic stem cells (HSCs) are incompletely understood. In this issue of Genes & Development, Burgess et al. (pp. 887-900) demonstrate a novel role of Bmi1 in regulating ribosome biogenesis and protein synthesis. Bmi1-deficient HSCs exhibited reduced transplantability, with the up-regulation of ARX and genes involved in ribosome biogenesis. However, depletion of ARX or its known targets, p16Ink4a/p19Arf , only partially rescues Bmi1 loss-induced hematopoietic defects. They further demonstrate an increased protein synthesis rate and resultant proteostatic stress in Bmi1-/- HSCs, indicating a novel mechanism by which Bmi1 controls HSC maintenance.

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Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
First
Funding Project
Southern University of Science and Technology[Y011286101] ; National Institutes of Health["R01DK127738","R01CA271523"]
WOS Research Area
Cell Biology ; Developmental Biology ; Genetics & Heredity
WOS Subject
Cell Biology ; Developmental Biology ; Genetics & Heredity
WOS Accession No
WOS:000870849800001
Publisher
Scopus EID
2-s2.0-85139571024
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/406589
DepartmentDepartment of Biochemistry
南方科技大学医学院
Affiliation
1.Department of Biochemistry,School of Medicine,Southern University of Science and Technology,Shenzhen,518000,China
2.Children's Hospital of Philadelphia; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
First Author AffilicationDepartment of Biochemistry;  School of Medicine
First Author's First AffilicationDepartment of Biochemistry;  School of Medicine
Recommended Citation
GB/T 7714
Lv,Kaosheng,Tong,Wei. A protein synthesis brake for hematopoietic stem cell maintenance[J]. Genes & development,2022,36(15-16):871-873.
APA
Lv,Kaosheng,&Tong,Wei.(2022).A protein synthesis brake for hematopoietic stem cell maintenance.Genes & development,36(15-16),871-873.
MLA
Lv,Kaosheng,et al."A protein synthesis brake for hematopoietic stem cell maintenance".Genes & development 36.15-16(2022):871-873.
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