| Title | Three-staged tumor inhibition by mitochondria-targeted cascaded gas/mild-photothermal/photodynamic synergistic therapy |
| Author | |
| Corresponding Author | Cheng, Mo; Li, Xianming; Duo, Yanhong |
| Publication Years | 2022-08-15
|
| DOI | |
| Source Title | |
| ISSN | 1385-8947
|
| EISSN | 1873-3212
|
| Volume | 442 |
| Abstract | The mitochondria critically determine the cell fates and therapeutic interventions. Contrary to the conventional and prevalent nanomaterial-based antitumor strategy, this study proposed a novel synergistic solution that accomplied with a dual tumor and mitochondria-specific BP@PDA-Ce6&SNP-TPP&FA (BCS) platform. The Ce6 and SNP were released in response to the tumor microenvironment and 660 nm laser irradiation. This induced the generation of NO, mild temperature, and ROS, and a second dynamic therapy (ONOO-), destroying the mitochondrial structure and inhibiting the mitochondrial function. The blockade of the mitochondrial function would hinder the cellular respiration and ATP supply, and also perturb the communication and cellular components between the mitochondria and lysosomes. Consequently, the BCS NPs exhibited better antitumor efficacy as well as excellent biosafety than the gas therapy (GT), mild photothermal therapy (mPTT), or photodynamic therapy (PDT) nanoagents individually. This novel cascaded GT/mPTT/PDT synergistic solution offering great potential for numerous anti-cancer treatments. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | National Natural Science Foundation of China[82102904]
; Science, Technology & Innovation Commission of Shenzhen Municipality["JCYJ20190807144605514","JCYJ20210324113405014","JCYJ20180305180540801","JCYJ 20180228175652675","JCYJ20210324113411032","JCYJ201 90808154213097"]
|
| WOS Research Area | Engineering
|
| WOS Subject | Engineering, Environmental
; Engineering, Chemical
|
| WOS Accession No | WOS:000866373200001
|
| Publisher | |
| ESI Research Field | ENGINEERING
|
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/406853 |
| Department | Shenzhen People's Hospital |
| Affiliation | 1.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1,Dept Radiat Oncol, Clin Med Coll 2,Shenzhen Peoples Hosp, Shenzhen 518020, Guangdong, Peoples R China 2.Fudan Univ, Shanghai Canc Ctr, Dept Musculoskeletal Surg, Dongan Rd, Shanghai 200032, Peoples R China 3.Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Stockholm, Sweden 4.Tsinghua Univ Shenzhen, Res Inst, Key Lab New Drug Res TCM, Shenzhen 518057, Guangdong, Peoples R China |
| First Author Affilication | Shenzhen People's Hospital |
| Corresponding Author Affilication | Shenzhen People's Hospital |
| First Author's First Affilication | Shenzhen People's Hospital |
| Recommended Citation GB/T 7714 |
Luo, Guanghong,Li, Zihuang,Chen, Meili,et al. Three-staged tumor inhibition by mitochondria-targeted cascaded gas/mild-photothermal/photodynamic synergistic therapy[J]. CHEMICAL ENGINEERING JOURNAL,2022,442.
|
| APA |
Luo, Guanghong.,Li, Zihuang.,Chen, Meili.,Zheng, Jiezhou.,Deng, Xiaonian.,...&Duo, Yanhong.(2022).Three-staged tumor inhibition by mitochondria-targeted cascaded gas/mild-photothermal/photodynamic synergistic therapy.CHEMICAL ENGINEERING JOURNAL,442.
|
| MLA |
Luo, Guanghong,et al."Three-staged tumor inhibition by mitochondria-targeted cascaded gas/mild-photothermal/photodynamic synergistic therapy".CHEMICAL ENGINEERING JOURNAL 442(2022).
|
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