中文版 | English
Title

Gossypol Broadly Inhibits Coronaviruses by Targeting RNA-Dependent RNA Polymerases

Author
Corresponding AuthorBu, Zhigao; Qu, Lingbo; Ren, Maozhi; Li, Fuguang
Publication Years
2022-10-01
DOI
Source Title
EISSN
2198-3844
Abstract
Outbreaks of coronaviruses (CoVs), especially severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have posed serious threats to humans and animals, which urgently calls for effective broad-spectrum antivirals. RNA-dependent RNA polymerase (RdRp) plays an essential role in viral RNA synthesis and is an ideal pan-coronaviral therapeutic target. Herein, based on cryo-electron microscopy and biochemical approaches, gossypol (GOS) is identified from 881 natural products to directly block SARS-CoV-2 RdRp, thus inhibiting SARS-CoV-2 replication in both cellular and mouse infection models. GOS also acts as a potent inhibitor against the SARS-CoV-2 variant of concern (VOC) and exerts same inhibitory effects toward mutated RdRps of VOCs as the RdRp of the original SARS-CoV-2. Moreover, that the RdRp inhibitor GOS has broad-spectrum anti-coronavirus activity against alphacoronaviruses (porcine epidemic diarrhea virus and swine acute diarrhea syndrome coronavirus), betacoronaviruses (SARS-CoV-2), gammacoronaviruses (avian infectious bronchitis virus), and deltacoronaviruses (porcine deltacoronavirus) is showed. The findings demonstrate that GOS may serve as a promising lead compound for combating the ongoing COVID-19 pandemic and other coronavirus outbreaks.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
Funding Project
National Key R&D Program of China[2020YFA0908002] ; National Natural Science Foundation of China["31621005","U1804231","31972469"] ; Key Science and Technology Research of Henan Province[222102310043]
WOS Research Area
Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS Subject
Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS Accession No
WOS:000870560000001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/406856
DepartmentSchool of Medicine
南方科技大学第一附属医院
南方科技大学第二附属医院
Affiliation
1.Zhengzhou Univ, Sch Agr Sci, State Key Lab Cotton Biol, Zhengzhou Res Base, Zhengzhou 450001, Henan, Peoples R China
2.Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin 150069, Heilongjiang, Peoples R China
3.Chinese Acad Agr Sci, Inst Cotton Res, Anyang 455000, Henan, Peoples R China
4.Chinese Acad Agr Sci, Inst Urban Agr, Chengdu 610213, Sichuan, Peoples R China
5.Hainan Yazhou Bay Seed Lab, Sanya 572025, Hainan, Peoples R China
6.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Affiliated Hosp 2, Natl Clin Res Ctr Infect Dis,Inst Hepatol,Sch Med, Shenzhen 518112, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Wang, Wenjing,Li, Wenkang,Wen, Zhiyuan,et al. Gossypol Broadly Inhibits Coronaviruses by Targeting RNA-Dependent RNA Polymerases[J]. ADVANCED SCIENCE,2022.
APA
Wang, Wenjing.,Li, Wenkang.,Wen, Zhiyuan.,Wang, Chong.,Liu, Weilong.,...&Li, Fuguang.(2022).Gossypol Broadly Inhibits Coronaviruses by Targeting RNA-Dependent RNA Polymerases.ADVANCED SCIENCE.
MLA
Wang, Wenjing,et al."Gossypol Broadly Inhibits Coronaviruses by Targeting RNA-Dependent RNA Polymerases".ADVANCED SCIENCE (2022).
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