| Title | Nickel-catalyzed enantioselective alpha-heteroarylation of ketones via C-F bond activation to construct all-carbon quaternary stereocenters |
| Author | |
| Corresponding Author | Li, Mingliang; Wang, Jun (Joelle) |
| Publication Years | 2022-10-01
|
| DOI | |
| Source Title | |
| ISSN | 2041-6520
|
| EISSN | 2041-6539
|
| Abstract | Nickel-catalyzed asymmetric alpha-heteroarylation of ketones with fluorinated heteroarenes is reported via C-F bond activation. A series of ketones and 2-fluoropyridine derivatives with different functional groups proceed well to provide the corresponding products containing all-carbon quaternary stereocenters in good yields (up to 99% yield) and high ee values (up to 99% ee). In addition, drug molecule donepezil could also be compatible under the reaction conditions to afford late-stage diversification of pharmaceuticals. |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| Important Publications | NI Journal Papers
|
| SUSTech Authorship | Corresponding
|
| Funding Project | National Natural Science Foundation of China[NSFC 21902072]
|
| WOS Research Area | Chemistry
|
| WOS Subject | Chemistry, Multidisciplinary
|
| WOS Accession No | WOS:000869858600001
|
| Publisher | |
| EI Accession Number | 20224613102634
|
| EI Keywords | Carbon
; Catalysis
; Chemical activation
; Nickel
|
| ESI Classification Code | Nickel:548.1
; Chemical Reactions:802.2
; Chemical Products Generally:804
; Organic Compounds:804.1
|
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/406860 |
| Department | Department of Chemistry |
| Affiliation | 1.Hong Kong Baptist Univ, Dept Chem, Kowloon, Hong Kong, Peoples R China 2.Southern Univ Sci & Technol SUSTech, Dept Chem, Shenzhen 518055, Peoples R China 3.Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 311121, Peoples R China |
| Corresponding Author Affilication | Department of Chemistry |
| Recommended Citation GB/T 7714 |
Gu, Xiaodong,Liu, Kexin,Yang, Limin,et al. Nickel-catalyzed enantioselective alpha-heteroarylation of ketones via C-F bond activation to construct all-carbon quaternary stereocenters[J]. Chemical Science,2022.
|
| APA |
Gu, Xiaodong,Liu, Kexin,Yang, Limin,Xie, Chengyi,Li, Mingliang,&Wang, Jun .(2022).Nickel-catalyzed enantioselective alpha-heteroarylation of ketones via C-F bond activation to construct all-carbon quaternary stereocenters.Chemical Science.
|
| MLA |
Gu, Xiaodong,et al."Nickel-catalyzed enantioselective alpha-heteroarylation of ketones via C-F bond activation to construct all-carbon quaternary stereocenters".Chemical Science (2022).
|
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