中文版 | English
Title

Classification and Prognostic Characteristics of Hepatocellular Carcinoma Based on Glycolysis Cholesterol Synthesis Axis

Author
Corresponding AuthorChen, Wenbiao
Publication Years
2022-09-30
DOI
Source Title
ISSN
1687-8450
EISSN
1687-8469
Volume2022
Abstract
Background. Liver hepatocellular carcinoma (LIHC) is among the most frequent causes of cancer-related death across the world with a considerably poor prognosis. The current study targeted providing a new type of LIHC from the perspective of the glycolysis/cholesterol synthesis axis, predicting its prognostic characteristics, and exploring the potential role and mechanism of the glycolysis/cholesterol synthesis axis in the occurrence and development of LIHC. Methods. Based on the two expression profile data and clinical information of LIHC in The Cancer Genome Atlas (TCGA) database and hepatocellular carcinoma database (HCCDB), as well as glycolysis/cholesterol-related genes from the Molecular Signatures Database (MSigDB), unsupervised consistent clustering method was used to identify molecular subtypes. In addition, the differential genes were identified by limma package, and then the gene set was enriched, analyzed, and annotated by WebGestaltR package. At the same time, the immune infiltration analysis of tumor samples was carried out using the ESTIMATE to evaluate the tumor immune score of the samples. Finally, the differences in clinical characteristics among molecular subtypes were measured using univariate and multivariate Cox analyses. Results. According to the median standardized expression levels of glycolysis/cholesterol production genes, samples were divided into four groups (molecular subtypes): Quiescent group, Glycolysis group, Cholesterol group, and Mixed group. Significant prognostic differences were observed among the four groups. In both TCGA and HCCDB18 datasets, the prognosis of subtype Mixed was the worst, while Quiescent had a good prognosis. Cell cycle and oncogenic pathways were significantly enriched in the Mixed group. In addition, glycolysis and cholesterol production gene expressions were related to the prognostic LIHC subtype classification genes' expression levels. Conclusion. Metabolic classification regarding glycolysis and cholesterol production pathways provided new insights into the biological aspects of LIHC molecular subtypes and might help to develop personalized therapies for unique tumor metabolic profiles.
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
Funding Project
Shenzhen Science and Technology[JCYJ20180306140810282] ; China Postdoctoral Foundation[2021M703372] ; Basic and Applied Basic Research Fund of Guangdong Province[2021A1515110967] ; Medical Research Fund of Guangdong[B2022103]
WOS Research Area
Oncology
WOS Subject
Oncology
WOS Accession No
WOS:000868325800005
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/406867
DepartmentShenzhen People's Hospital
Affiliation
1.Southern Med Univ, Shenzhen Pingshan Dist Peoples Hosp, Pingshan Gen Hosp, Clin Skills Ctr, Shenzhen 518000, Peoples R China
2.Southern Med Univ, Shenzhen Pingshan Dist Peoples Hosp, Pingshan Gen Hosp, Cent Lab, Shenzhen 518000, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Dept Clin Med,Res Ctr,Clin Med Coll 2,Jinan Univ, Shenzhen 518000, Peoples R China
4.Southern Med Univ, Peoples Hosp Longhua, Cent Mol Lab, Affiliated Hosp, Shenzhen 518000, Peoples R China
5.Southern Med Univ, Peoples Hosp Longhua, Dept Resp Med, Affiliated Hosp, Shenzhen 518000, Peoples R China
Recommended Citation
GB/T 7714
Deng, Weijie,Zhu, Peng,Xu, Huixuan,et al. Classification and Prognostic Characteristics of Hepatocellular Carcinoma Based on Glycolysis Cholesterol Synthesis Axis[J]. Journal of Oncology,2022,2022.
APA
Deng, Weijie,Zhu, Peng,Xu, Huixuan,Hou, Xianliang,&Chen, Wenbiao.(2022).Classification and Prognostic Characteristics of Hepatocellular Carcinoma Based on Glycolysis Cholesterol Synthesis Axis.Journal of Oncology,2022.
MLA
Deng, Weijie,et al."Classification and Prognostic Characteristics of Hepatocellular Carcinoma Based on Glycolysis Cholesterol Synthesis Axis".Journal of Oncology 2022(2022).
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