Early Antimicrobial Evaluation of Nanostructured Surfaces Based on Bacterial Biological Properties

Liu，Pingting1,2; Zhao，Zhili3; Tang，Jincheng4; Wang，Anqi2; Zhao，Dapeng2; Yang，Yan1

2022

10.1021/acsbiomaterials.2c00559

ACS Biomaterials Science and Engineering   Impact Factor & Quartile

2373-9878

2373-9878

Nanostructured physical antibacterial surfaces are of great interest due to the increasing antibiotic resistance. In this work, the titania nanotube (TNT) array, a potential physical antibacterial surface, was used for antimicrobial evaluation. The early antibacterial properties of TNTs were assessed based on three growth phases of Staphylococcus aureus (S. aureus), and the physical factors influencing the antibacterial properties were comprehensively discussed. The results show apparent early antibacterial effects of TNTs, including the anti-initial attachment during the lag phase, the inhibition of proliferation and bactericidal effect during the logarithmic phase, and the inhibition of biofilm formation during the stationary phase. These antimicrobial effects are closely related to the combined influence of various physical properties of TNTs, such as diameter, hydrophilicity, roughness, and charge. The present work suggests that the evaluation of the early antimicrobial behavior of biomaterials should pay more attention on the biological characteristics of bacteria.

bacterial growth phase early antibacterial properties nanostructured surfaces titania nanotubes

SCI

English

Others

National Natural Science Foundation of China["81702709","52171114"] ; Innovation-oriented Advanced Technology and Industrial Technology Program Project of Hunan Province[2020SK2017] ; Hunan Provincial Natural Science Foundation of China[2020JJ4459] ; Hunan Provincial Innovation Foundation for Postgraduate[CX20200267] ; Fundamental Research Funds for Central South University[2020zzts788] ; Central South University Postgraduate Education and Teaching Reform Project[2020JGB116]

Materials Science

Materials Science, Biomaterials

WOS:000870296900001

AMER CHEMICAL SOC

2-s2.0-85140024507

Scopus

1.Hunan Key Laboratory of Oral Health Research,Xiangya Stomatological Hospital,Xiangya School of Stomatology,Central South University,Changsha,Hunan,410008,China
2.College of Biology,Hunan University,Changsha,Hunan,410082,China
3.Department of Oral and Maxillofacial Surgery,The Second Xiangya Hospital,Central South University,Changsha,Hunan,410010,China
4.Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China

Liu，Pingting,Zhao，Zhili,Tang，Jincheng,et al. Early Antimicrobial Evaluation of Nanostructured Surfaces Based on Bacterial Biological Properties[J]. ACS Biomaterials Science and Engineering,2022.

Liu，Pingting,Zhao，Zhili,Tang，Jincheng,Wang，Anqi,Zhao，Dapeng,&Yang，Yan.(2022).Early Antimicrobial Evaluation of Nanostructured Surfaces Based on Bacterial Biological Properties.ACS Biomaterials Science and Engineering.

Liu，Pingting,et al."Early Antimicrobial Evaluation of Nanostructured Surfaces Based on Bacterial Biological Properties".ACS Biomaterials Science and Engineering (2022).