中文版 | English
Title

Recent advances on bioactive baghdadite ceramic for bone tissue engineering applications: 20 years of research and innovation (a review)

Author
Corresponding AuthorSadeghzade,Sorour; Yuan,Hongyan
Publication Years
2022-10-25
DOI
Source Title
ISSN
2590-0064
EISSN
2590-0064
Volume17
Abstract

Various artificial bone graft substitutes based on ceramics have been developed over the last 20 years. Among them, calcium-silicate-based ceramics, which are osteoconductive and can attach directly to biological organs, have received great attention for bone tissue engineering applications. However, the degradation rate of calcium-silicate and bone formation is often out of balance, resulting in stress shielding (osteopenia). A new strategy to improve the drawbacks of these ceramics is incorporating trace elements such as Zn, Mg, and Zr into their lattice structures, enhancing their physical and biological properties. Recently, baghdadite (CaZrSiO) ceramic, one of the most appealing calcium-silicate-based ceramics, has demonstrated high bioactivity, biocompatibility, biodegradability, and cell interaction. Because of its physical, mechanical, and biological properties and ability to be shaped using various fabrication techniques, baghdadite has found high potential in various biomedical applications such as coatings, fillers, cement, scaffolds, and drug delivery systems. Undoubtedly, there is a high potential for this newly developed ceramic to contribute significantly to therapies to provide a tremendous clinical outcome. This review paper aims to summarize and discuss the most relevant studies performed on baghdadite-based ceramics and composites by focusing on their behavior in vivo and in vitro.

Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
First ; Corresponding
Funding Project
Science, Technology and Innovation Commission of Shenzhen Municipality[ZDSYS20210623092005017]
WOS Research Area
Engineering ; Materials Science
WOS Subject
Engineering, Biomedical ; Materials Science, Biomaterials
WOS Accession No
WOS:000883714400002
Publisher
Scopus EID
2-s2.0-85140878826
Data Source
Scopus
Citation statistics
Cited Times [WOS]:6
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/407083
DepartmentDepartment of Mechanics and Aerospace Engineering
南方科技大学医学院
工学院_生物医学工程系
南方科技大学医学院_生物化学系
Affiliation
1.Shenzhen Key Laboratory of Soft Mechanics & Smart Manufacturing,Department of Mechanics and Aerospace Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.Department of Biochemistry,School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China
3.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
First Author AffilicationDepartment of Mechanics and Aerospace Engineering
Corresponding Author AffilicationDepartment of Mechanics and Aerospace Engineering
First Author's First AffilicationDepartment of Mechanics and Aerospace Engineering
Recommended Citation
GB/T 7714
Sadeghzade,Sorour,Liu,Jingyi,Wang,Huiru,et al. Recent advances on bioactive baghdadite ceramic for bone tissue engineering applications: 20 years of research and innovation (a review)[J]. Materials Today Bio,2022,17.
APA
Sadeghzade,Sorour.,Liu,Jingyi.,Wang,Huiru.,Li,Xin.,Cao,Jinrui.,...&Yuan,Hongyan.(2022).Recent advances on bioactive baghdadite ceramic for bone tissue engineering applications: 20 years of research and innovation (a review).Materials Today Bio,17.
MLA
Sadeghzade,Sorour,et al."Recent advances on bioactive baghdadite ceramic for bone tissue engineering applications: 20 years of research and innovation (a review)".Materials Today Bio 17(2022).
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