南方科技大学知识苑(SUSTech KC): Neuro–epithelial

Title	Neuro–epithelial–ILC2 crosstalk in barrier tissues
Author	Yin，Ziyi 1; Zhou，Yawen 1; Turnquist，Hēth R.2; Liu，Quan1
Corresponding Author	Liu，Quan
Publication Years	2022-11-01
DOI	10.1016/j.it.2022.09.006
Source Title	TRENDS IN IMMUNOLOGY Impact Factor & Quartile
ISSN	1471-4906
EISSN	1471-4981
Volume	43 Issue:11Pages:901-916
Abstract	Group 2 innate lymphoid cells (ILC2s) contribute to the maintenance of mammalian barrier tissue homeostasis. We review how ILC2s integrate epithelial signals and neurogenic components to preserve the tissue microenvironment and modulate inflammation. The epithelium that overlies barrier tissues, including the skin, lungs, and gut, generates epithelial cytokines that elicit ILC2 activation. Sympathetic, parasympathetic, sensory, and enteric fibers release neural signals to modulate ILC2 functions. We also highlight recent findings suggesting neuro–epithelial–ILC2 crosstalk and its implications in immunity, inflammation and resolution, tissue repair, and restoring homeostasis. We further discuss the pathogenic effects of disturbed ILC2-centered neuro–epithelial–immune cell interactions and putative areas for therapeutic targeting.
Keywords	barrier tissue homeostasis ILC2 inflammation neuro–epithelial–immune unit
URL	[Source Record]
Indexed By	SCI
Language	English
SUSTech Authorship	First ; Corresponding
Funding Project	National Natural Science Foundation of China[81971507];National Institutes of Health[R01AR073527];National Institutes of Health[R01HL122489];National Institutes of Health[R56AI139327];
WOS Research Area	Immunology
WOS Subject	Immunology
WOS Accession No	WOS:000912958800010
Publisher	ELSEVIER SCI LTD
ESI Research Field	IMMUNOLOGY
Scopus EID	2-s2.0-85140351971
Data Source	Scopus
Citation statistics	Cited Times [WOS]:0
Document Type	Journal Article
Identifier	http://kc.sustech.edu.cn/handle/2SGJ60CL/407096
Department	Department of Biochemistry 南方科技大学医学院
Affiliation	1.Department of Biochemistry,School of Medicine,Southern University of Science and Technology,Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine,Shenzhen,Guangdong Province,518055,China 2.Thomas E. Starzl Transplantation Institute and Department of Surgery,University of Pittsburgh School of Medicine,Pittsburgh,15213,United States
First Author Affilication	Department of Biochemistry; School of Medicine
Corresponding Author Affilication	Department of Biochemistry; School of Medicine
First Author's First Affilication	Department of Biochemistry; School of Medicine
Recommended Citation GB/T 7714	Yin，Ziyi,Zhou，Yawen,Turnquist，Hēth R.,等. Neuro–epithelial–ILC2 crosstalk in barrier tissues[J]. TRENDS IN IMMUNOLOGY,2022,43(11):901-916.
APA	Yin，Ziyi,Zhou，Yawen,Turnquist，Hēth R.,&Liu，Quan.(2022).Neuro–epithelial–ILC2 crosstalk in barrier tissues.TRENDS IN IMMUNOLOGY,43(11),901-916.
MLA	Yin，Ziyi,et al."Neuro–epithelial–ILC2 crosstalk in barrier tissues".TRENDS IN IMMUNOLOGY 43.11(2022):901-916.

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Neuro–epithelial–ILC2 crosstalk in barrier tissues