中文版 | English
Title

Targeting aldehyde dehydrogenase for prostate cancer therapies

Author
Corresponding AuthorXia,Siyuan; Zhang,Baotong
Joint first authorHe,Wenyou; Zhao,Keyu; Xue,Linyuan; Xia,Siyuan
Publication Years
2022-10-10
DOI
Source Title
ISSN
2234-943X
EISSN
2234-943X
Volume12
Abstract

Prostate cancer (PCa) is the most common cancer in men in the United States. About 10 – 20% of PCa progress to castration-resistant PCa (CRPC), which is accompanied by metastasis and therapeutic resistance. Aldehyde dehydrogenase (ALDH) is famous as a marker of cancer stem-like cells in different cancer types, including PCa. Generally, ALDHs catalyze aldehyde oxidation into less toxic carboxylic acids and give cancers a survival advantage by reducing oxidative stress caused by aldehyde accumulation. In PCa, the expression of ALDHs is associated with a higher tumor stage and more lymph node metastasis. Functionally, increased ALDH activity makes PCa cells gain more capabilities in self-renewal and metastasis and reduces the sensitivity to castration and radiotherapy. Therefore, it is promising to target ALDH or ALDH cells to eradicate PCa. However, challenges remain in moving the ALDH inhibitors to PCa therapy, potentially due to the toxicity of pan-ALDH inhibitors, the redundancy of ALDH isoforms, and the lack of explicit understanding of the metabolic signaling transduction details. For targeting PCa stem-like cells (PCSCs), different regulators have been revealed in ALDH cells to control cell proliferation and tumorigenicity. ALDH rewires essential signaling transduction in PCa cells. It has been shown that ALDHs produce retinoic acid (RA), bind with androgen, and modulate diverse signaling. This review summarizes and discusses the pathways directly modulated by ALDHs, the crucial regulators that control the activities of ALDH PCSCs, and the recent progress of ALDH targeted therapies in PCa. These efforts will provide insight into improving ALDH-targeted treatment.

Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
First ; 共同第一 ; Corresponding
Funding Project
[2021A1515110051] ; [2021A1515110144]
WOS Research Area
Oncology
WOS Subject
Oncology
WOS Accession No
WOS:000874592200001
Publisher
Scopus EID
2-s2.0-85140323714
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/407116
DepartmentDepartment of Human Cell Biology and Genetics
南方科技大学医学院
Affiliation
Department of Human Cell Biology and Genetics,School of Medicine,Southern University of Science and Technology,Shenzhen,China
First Author AffilicationDepartment of Human Cell Biology and Genetics;  School of Medicine
Corresponding Author AffilicationDepartment of Human Cell Biology and Genetics;  School of Medicine
First Author's First AffilicationDepartment of Human Cell Biology and Genetics;  School of Medicine
Recommended Citation
GB/T 7714
Ma,Miao,He,Wenyou,Zhao,Keyu,et al. Targeting aldehyde dehydrogenase for prostate cancer therapies[J]. Frontiers in Oncology,2022,12.
APA
Ma,Miao,He,Wenyou,Zhao,Keyu,Xue,Linyuan,Xia,Siyuan,&Zhang,Baotong.(2022).Targeting aldehyde dehydrogenase for prostate cancer therapies.Frontiers in Oncology,12.
MLA
Ma,Miao,et al."Targeting aldehyde dehydrogenase for prostate cancer therapies".Frontiers in Oncology 12(2022).
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