中文版 | English
Title

小胶质细胞表型转换在脑缺血再灌注中作用的研究进展

Alternative Title
Research Progress on the Role of Microglia Phenotypic Transformation in Cerebral Ischemia Reperfusion
Author
Publication Years
2022
DOI
Source Title
ISSN
1007-0893
Volume32Issue:14Pages:133-136
Abstract
小胶质细胞是神经系统免疫的重要组成部分,脑缺血再灌注(CIR)是缺血性卒中损伤加重的重要机制之一,小胶质细胞与CIR中炎症反应关系密切.受不同因子途径影响,小胶质细胞被活化并表型转换为M1、M2不同亚型,调节小分子核糖核酸miRNA-139、miRNA-137、长链非编码核糖核酸(lncRNA)-U90926基因片段等基因的表达,抑制或激活NOD样受体蛋白3(NLRP3)/半胱氨酸的天冬氨酸蛋白水解酶1(caspase-1)、Notch等通路,从而产生促炎、抗炎作用,在CIR中呈现构筑炎症反应并参与炎症修复双向调节作用.
Keywords
URL[Source Record]
Language
Chinese
SUSTech Authorship
Others
Funding Project
深圳市科创委自然基金面上项目 ; 广东省自然科学基金
Data Source
WanFang
WanFangID
szzxyjhzz202214041
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/411623
DepartmentSouthern University of Science and Technology
Affiliation
南方科技大学盐田医院,广东深圳518083
Recommended Citation
GB/T 7714
梁晓瑜,郑丽芳. 小胶质细胞表型转换在脑缺血再灌注中作用的研究进展[J]. 深圳中西医结合杂志,2022,32(14):133-136.
APA
梁晓瑜,&郑丽芳.(2022).小胶质细胞表型转换在脑缺血再灌注中作用的研究进展.深圳中西医结合杂志,32(14),133-136.
MLA
梁晓瑜,et al."小胶质细胞表型转换在脑缺血再灌注中作用的研究进展".深圳中西医结合杂志 32.14(2022):133-136.
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