中文版 | English
Title

Use of a glycomics array to establish the anti-carbohydrate antibody repertoire in type 1 diabetes

Author
Corresponding AuthorPurohit,Sharad
Publication Years
2022-12-01
DOI
Source Title
EISSN
2041-1723
Volume13Issue:1
Abstract
Type 1 diabetes (T1D) is an autoimmune disease, characterized by the presence of autoantibodies to protein and non-protein antigens. Here we report the identification of specific anti-carbohydrate antibodies (ACAs) that are associated with pathogenesis and progression to T1D. We compare circulatory levels of ACAs against 202 glycans in a cross-sectional cohort of T1D patients (n = 278) and healthy controls (n = 298), as well as in a longitudinal cohort (n = 112). We identify 11 clusters of ACAs associated with glycan function class. Clusters enriched for aminoglycosides, blood group A and B antigens, glycolipids, ganglio-series, and O-linked glycans are associated with progression to T1D. ACAs against gentamicin and its related structures, G418 and sisomicin, are also associated with islet autoimmunity. ACAs improve discrimination of T1D status of individuals over a model with only clinical variables and are potential biomarkers for T1D.
URL[Source Record]
Indexed By
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
Others
Funding Project
Leona M. and Harry B. Helmsley Charitable Trust[G-1901-03687];Division of Cancer Epidemiology and Genetics, National Cancer Institute[R21CA199868];Division of Cancer Epidemiology and Genetics, National Cancer Institute[U01CA221242];
WOS Research Area
Science & Technology - Other Topics
WOS Subject
Multidisciplinary Sciences
WOS Accession No
WOS:000877942800001
Publisher
Scopus EID
2-s2.0-85140936101
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/411783
DepartmentSchool of Medicine
Affiliation
1.Center for Biotechnology and Genomic Medicine,Medical College of Georgia,Augusta University,Augusta,1120 15th Street,30912,United States
2.Department of Internal Medicine,Yale School of Medicine,New Haven,CT06510,United States
3.Barbara Davis Center for Diabetes,University of Colorado Denver,Mail Stop A-140,Aurora,1775 Aurora Court,80045,United States
4.Department of Surgery,Beth Israel Deaconess Medical Center,Harvard Medical School,Boston,02115,United States
5.School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
6.Department of Obstetrics and Gynecology,Medical College of Georgia,Augusta University,Augusta,1120 15th Street,30912,United States
7.Department of Undergraduate Health Professionals,College of Allied Health Sciences Augusta University,Augusta,1120 15th Street,30912,United States
Recommended Citation
GB/T 7714
Tran,Paul M.H.,Dong,Fran,Kim,Eileen,et al. Use of a glycomics array to establish the anti-carbohydrate antibody repertoire in type 1 diabetes[J]. Nature Communications,2022,13(1).
APA
Tran,Paul M.H..,Dong,Fran.,Kim,Eileen.,Richardson,Katherine P..,Tran,Lynn K.H..,...&Purohit,Sharad.(2022).Use of a glycomics array to establish the anti-carbohydrate antibody repertoire in type 1 diabetes.Nature Communications,13(1).
MLA
Tran,Paul M.H.,et al."Use of a glycomics array to establish the anti-carbohydrate antibody repertoire in type 1 diabetes".Nature Communications 13.1(2022).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Export to Excel
Export to Csv
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Tran,Paul M.H.]'s Articles
[Dong,Fran]'s Articles
[Kim,Eileen]'s Articles
Baidu Scholar
Similar articles in Baidu Scholar
[Tran,Paul M.H.]'s Articles
[Dong,Fran]'s Articles
[Kim,Eileen]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Tran,Paul M.H.]'s Articles
[Dong,Fran]'s Articles
[Kim,Eileen]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.