中文版 | English
Title

Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance

Author
Corresponding AuthorHu,Hailiang
Publication Years
2022-11-01
DOI
Source Title
ISSN
1661-6596
EISSN
1422-0067
Volume23Issue:21
Abstract

All aspects of prostate cancer evolution are closely related to androgen levels and the status of the androgen receptor (AR). Almost all treatments target androgen metabolism pathways and AR, from castration-sensitive prostate cancer (CSPC) to castration-resistant prostate cancer (CRPC). Alterations in androgen metabolism and its response are one of the main reasons for prostate cancer drug resistance. In this review, we will introduce androgen metabolism, including how the androgen was synthesized, consumed, and responded to in healthy people and prostate cancer patients, and discuss how these alterations in androgen metabolism contribute to the resistance to anti-androgen therapy.

Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
First ; Corresponding
Funding Project
National Natural Science Foundation of China[82173131] ; Science and Technology Innovation Commission of Shenzhen Municipal Government[JCYJ20210324104007022]
WOS Research Area
Biochemistry & Molecular Biology ; Chemistry
WOS Subject
Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS Accession No
WOS:000882188200001
Publisher
ESI Research Field
CHEMISTRY
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:2
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/411815
DepartmentDepartment of Biochemistry
南方科技大学医学院
Affiliation
1.Department of Biochemistry,School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China
2.Key University Laboratory of Metabolism and Health of Guangdong,Southern University of Science and Technology,Shenzhen,518055,China
First Author AffilicationDepartment of Biochemistry;  School of Medicine
Corresponding Author AffilicationDepartment of Biochemistry;  School of Medicine;  Southern University of Science and Technology
First Author's First AffilicationDepartment of Biochemistry;  School of Medicine
Recommended Citation
GB/T 7714
Zhang,Haozhe,Zhou,Yi,Xing,Zengzhen,et al. Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance[J]. International Journal of Molecular Sciences,2022,23(21).
APA
Zhang,Haozhe,Zhou,Yi,Xing,Zengzhen,Sah,Rajiv Kumar,Hu,Junqi,&Hu,Hailiang.(2022).Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance.International Journal of Molecular Sciences,23(21).
MLA
Zhang,Haozhe,et al."Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance".International Journal of Molecular Sciences 23.21(2022).
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