Selective and stable tetraphosphite for Rh-catalyzed linear hydroaminomethylation of aliphatic and aromatic terminal olefins

Yan，Xin1; Zhang，Runtong1; Wang，Jiang1; Yu，Hongyi3; Wen，Jialin2; Bai，Shao Tao2; Zhang，Xumu1

2022-10-20

10.1039/d2re00400c

Reaction Chemistry & Engineering   Impact Factor & Quartile

2058-9883

2058-9883

A selective and stable tetraphosphite ligand was reported for rhodium-catalyzed linear hydroaminomethylation of aliphatic and aromatic terminal olefins with an unprecedentedly high TOF (up to 12 060 h), high chemoselectivities (up to 99.9% amine) and high regioselectivities (up to 99.9% linear isomer). Such a catalytic method demonstrates a practical and straightforward route to the billion-dollar drug cinacalcet at a remarkably high catalyst efficiency and atom economy (S/C = 10 000).

SCI ; EI

English

First ; Corresponding

National Natural Science Foundation of China[22001113] ; Science and Technology Innovation Committee of Shenzhen[JCYJ20170817104824122] ; Guangdong Basic and Applied Basic Research Foundation[2021A1515110808] ; National Key R&D Program of China[2021YFA1500201]

Chemistry ; Engineering

Chemistry, Multidisciplinary ; Engineering, Chemical

WOS:000874485600001

ROYAL SOC CHEMISTRY

20224613128636

Aromatic compounds ; Olefins

Chemical Reactions:802.2 ; Organic Compounds:804.1

2-s2.0-85141885518

Scopus

1.Guangdong Provincial Key Laboratory of Catalysis,Department of Chemistry,Southern University of Science and Technology,Shenzhen,518055,China
2.Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,518055,China
3.Homerton College,University of Cambridge,Cambridgeshire,CB2 8PH,United Kingdom

Yan，Xin,Zhang，Runtong,Wang，Jiang,et al. Selective and stable tetraphosphite for Rh-catalyzed linear hydroaminomethylation of aliphatic and aromatic terminal olefins[J]. Reaction Chemistry & Engineering,2022,118.

Yan，Xin.,Zhang，Runtong.,Wang，Jiang.,Yu，Hongyi.,Wen，Jialin.,...&Zhang，Xumu.(2022).Selective and stable tetraphosphite for Rh-catalyzed linear hydroaminomethylation of aliphatic and aromatic terminal olefins.Reaction Chemistry & Engineering,118.

Yan，Xin,et al."Selective and stable tetraphosphite for Rh-catalyzed linear hydroaminomethylation of aliphatic and aromatic terminal olefins".Reaction Chemistry & Engineering 118(2022).