Title | Promising strategy for developing mRNA-based universal influenza virus vaccine for human population, poultry, and pigs– focus on the bigger picture |
Author | |
Corresponding Author | He,Yunjiao; Wang,Peng George |
Publication Years | 2022-10-17
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DOI | |
Source Title | |
ISSN | 1664-3224
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EISSN | 1664-3224
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Volume | 13 |
Abstract | Since the first outbreak in the 19 century influenza virus has remained emergent owing to the huge pandemic potential. Only the pandemic of 1918 caused more deaths than any war in world history. Although two types of influenza– A (IAV) and B (IBV) cause epidemics annually, influenza A deserves more attention as its nature is much wilier. IAVs have a large animal reservoir and cause the infection manifestation not only in the human population but in poultry and domestic pigs as well. This many-sided characteristic of IAV along with the segmented genome gives rise to the antigenic drift and shift that allows evolving the new strains and new subtypes, respectively. As a result, the immune system of the body is unable to recognize them. Importantly, several highly pathogenic avian IAVs have already caused sporadic human infections with a high fatality rate (~60%). The current review discusses the promising strategy of using a potentially universal IAV mRNA vaccine based on conserved elements for humans, poultry, and pigs. This will better aid in averting the outbreaks in different susceptible species, thus, reduce the adverse impact on agriculture, and economics, and ultimately, prevent deadly pandemics in the human population. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
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SUSTech Authorship | First
; Corresponding
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Funding Project | Shenzhen Science and Technology Innovation Program[KQTD20200909113758004];
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WOS Research Area | Immunology
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WOS Subject | Immunology
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WOS Accession No | WOS:000877964700001
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Publisher | |
Scopus EID | 2-s2.0-85140978315
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Data Source | Scopus
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Citation statistics |
Cited Times [WOS]:2
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/411835 |
Department | Department of Pharmacology 南方科技大学医学院 |
Affiliation | Department of Pharmacology,School of Medicine,Southern University of Science and Technology,Shenzhen,China |
First Author Affilication | Department of Pharmacology; School of Medicine |
Corresponding Author Affilication | Department of Pharmacology; School of Medicine |
First Author's First Affilication | Department of Pharmacology; School of Medicine |
Recommended Citation GB/T 7714 |
Rcheulishvili,Nino,Papukashvili,Dimitri,Liu,Cong,等. Promising strategy for developing mRNA-based universal influenza virus vaccine for human population, poultry, and pigs– focus on the bigger picture[J]. Frontiers in Immunology,2022,13.
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APA |
Rcheulishvili,Nino,Papukashvili,Dimitri,Liu,Cong,Ji,Yang,He,Yunjiao,&Wang,Peng George.(2022).Promising strategy for developing mRNA-based universal influenza virus vaccine for human population, poultry, and pigs– focus on the bigger picture.Frontiers in Immunology,13.
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MLA |
Rcheulishvili,Nino,et al."Promising strategy for developing mRNA-based universal influenza virus vaccine for human population, poultry, and pigs– focus on the bigger picture".Frontiers in Immunology 13(2022).
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