中文版 | English
Title

Promising strategy for developing mRNA-based universal influenza virus vaccine for human population, poultry, and pigs– focus on the bigger picture

Author
Corresponding AuthorHe,Yunjiao; Wang,Peng George
Publication Years
2022-10-17
DOI
Source Title
ISSN
1664-3224
EISSN
1664-3224
Volume13
Abstract
Since the first outbreak in the 19 century influenza virus has remained emergent owing to the huge pandemic potential. Only the pandemic of 1918 caused more deaths than any war in world history. Although two types of influenza– A (IAV) and B (IBV) cause epidemics annually, influenza A deserves more attention as its nature is much wilier. IAVs have a large animal reservoir and cause the infection manifestation not only in the human population but in poultry and domestic pigs as well. This many-sided characteristic of IAV along with the segmented genome gives rise to the antigenic drift and shift that allows evolving the new strains and new subtypes, respectively. As a result, the immune system of the body is unable to recognize them. Importantly, several highly pathogenic avian IAVs have already caused sporadic human infections with a high fatality rate (~60%). The current review discusses the promising strategy of using a potentially universal IAV mRNA vaccine based on conserved elements for humans, poultry, and pigs. This will better aid in averting the outbreaks in different susceptible species, thus, reduce the adverse impact on agriculture, and economics, and ultimately, prevent deadly pandemics in the human population.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
First ; Corresponding
Funding Project
Shenzhen Science and Technology Innovation Program[KQTD20200909113758004];
WOS Research Area
Immunology
WOS Subject
Immunology
WOS Accession No
WOS:000877964700001
Publisher
Scopus EID
2-s2.0-85140978315
Data Source
Scopus
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/411835
DepartmentDepartment of Pharmacology
南方科技大学医学院
Affiliation
Department of Pharmacology,School of Medicine,Southern University of Science and Technology,Shenzhen,China
First Author AffilicationDepartment of Pharmacology;  School of Medicine
Corresponding Author AffilicationDepartment of Pharmacology;  School of Medicine
First Author's First AffilicationDepartment of Pharmacology;  School of Medicine
Recommended Citation
GB/T 7714
Rcheulishvili,Nino,Papukashvili,Dimitri,Liu,Cong,等. Promising strategy for developing mRNA-based universal influenza virus vaccine for human population, poultry, and pigs– focus on the bigger picture[J]. Frontiers in Immunology,2022,13.
APA
Rcheulishvili,Nino,Papukashvili,Dimitri,Liu,Cong,Ji,Yang,He,Yunjiao,&Wang,Peng George.(2022).Promising strategy for developing mRNA-based universal influenza virus vaccine for human population, poultry, and pigs– focus on the bigger picture.Frontiers in Immunology,13.
MLA
Rcheulishvili,Nino,et al."Promising strategy for developing mRNA-based universal influenza virus vaccine for human population, poultry, and pigs– focus on the bigger picture".Frontiers in Immunology 13(2022).
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