Title | Highly efficient and enantioselective synthesis of β-heteroaryl amino alcohols via Ru-catalyzed asymmetric hydrogenation |
Author | |
Corresponding Author | Ma,Baode; Zhang,Xumu |
Publication Years | 2022-10-13
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DOI | |
Source Title | |
ISSN | 1359-7345
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EISSN | 1364-548X
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Volume | 31Issue:17-19 |
Abstract | Chiral β-heteroaryl amino alcohols are key fragments of many bioactive compounds and antibiotics, and the development of efficient synthetic methods for these compounds is of great value. The highly enantioselective hydrogenation of α-N-heteroaryl ketones was realized with a ruthenium-diphosphine-diamine catalyst, providing the corresponding chiral β-heteroaryl amino alcohols with up to 99% yield and up to >99% ee. The synthetic utilities of the current reaction were demonstrated by gram-scale synthesis of key intermediates of Sertaconazole and Cenobamate. |
URL | [Source Record] |
Indexed By | |
Language | English
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Important Publications | NI Journal Papers
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SUSTech Authorship | Corresponding
|
Funding Project | National Key R&D Program of China[2021YFA1500201]
; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002]
; Shenzhen Science and Technology Innovation Committee[JCYJ20210324104202007]
; National Natural Science Foundation of China["22001113","21901107","22171129"]
; Stable Support Plan Program of Shenzhen Natural Science Fund[20200925161222002]
; Guangdong Basic and Applied Basic Research Foundation[2022B1515020055]
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WOS Research Area | Chemistry
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WOS Subject | Chemistry, Multidisciplinary
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WOS Accession No | WOS:000874485200001
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Publisher | |
ESI Research Field | CHEMISTRY
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Scopus EID | 2-s2.0-85141510263
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Data Source | Scopus
|
Citation statistics |
Cited Times [WOS]:0
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/411838 |
Department | Department of Chemistry 前沿与交叉科学研究院 深圳格拉布斯研究院 |
Affiliation | 1.School of Chemistry and Chemical Engineering,Harbin Institute of Technology,Harbin,150001,China 2.Shenzhen Grubbs Institute,Department of Chemistry,Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen,518055,China 3.Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,518000,China 4.Shenzhen Bay Laboratory,Shenzhen,518132,China |
First Author Affilication | Department of Chemistry; Shenzhen Grubbs Institute |
Corresponding Author Affilication | Department of Chemistry; Shenzhen Grubbs Institute |
Recommended Citation GB/T 7714 |
Wu,Chao,Ma,Baode,Chen,Gen Qiang,et al. Highly efficient and enantioselective synthesis of β-heteroaryl amino alcohols via Ru-catalyzed asymmetric hydrogenation[J]. CHEMICAL COMMUNICATIONS,2022,31(17-19).
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APA |
Wu,Chao,Ma,Baode,Chen,Gen Qiang,&Zhang,Xumu.(2022).Highly efficient and enantioselective synthesis of β-heteroaryl amino alcohols via Ru-catalyzed asymmetric hydrogenation.CHEMICAL COMMUNICATIONS,31(17-19).
|
MLA |
Wu,Chao,et al."Highly efficient and enantioselective synthesis of β-heteroaryl amino alcohols via Ru-catalyzed asymmetric hydrogenation".CHEMICAL COMMUNICATIONS 31.17-19(2022).
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