中文版 | English
Title

Highly efficient and enantioselective synthesis of β-heteroaryl amino alcohols via Ru-catalyzed asymmetric hydrogenation

Author
Corresponding AuthorMa,Baode; Zhang,Xumu
Publication Years
2022-10-13
DOI
Source Title
ISSN
1359-7345
EISSN
1364-548X
Volume31Issue:17-19
Abstract
Chiral β-heteroaryl amino alcohols are key fragments of many bioactive compounds and antibiotics, and the development of efficient synthetic methods for these compounds is of great value. The highly enantioselective hydrogenation of α-N-heteroaryl ketones was realized with a ruthenium-diphosphine-diamine catalyst, providing the corresponding chiral β-heteroaryl amino alcohols with up to 99% yield and up to >99% ee. The synthetic utilities of the current reaction were demonstrated by gram-scale synthesis of key intermediates of Sertaconazole and Cenobamate.
URL[Source Record]
Indexed By
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
Corresponding
Funding Project
National Key R&D Program of China[2021YFA1500201] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002] ; Shenzhen Science and Technology Innovation Committee[JCYJ20210324104202007] ; National Natural Science Foundation of China["22001113","21901107","22171129"] ; Stable Support Plan Program of Shenzhen Natural Science Fund[20200925161222002] ; Guangdong Basic and Applied Basic Research Foundation[2022B1515020055]
WOS Research Area
Chemistry
WOS Subject
Chemistry, Multidisciplinary
WOS Accession No
WOS:000874485200001
Publisher
ESI Research Field
CHEMISTRY
Scopus EID
2-s2.0-85141510263
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/411838
DepartmentDepartment of Chemistry
前沿与交叉科学研究院
深圳格拉布斯研究院
Affiliation
1.School of Chemistry and Chemical Engineering,Harbin Institute of Technology,Harbin,150001,China
2.Shenzhen Grubbs Institute,Department of Chemistry,Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen,518055,China
3.Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,518000,China
4.Shenzhen Bay Laboratory,Shenzhen,518132,China
First Author AffilicationDepartment of Chemistry;  Shenzhen Grubbs Institute
Corresponding Author AffilicationDepartment of Chemistry;  Shenzhen Grubbs Institute
Recommended Citation
GB/T 7714
Wu,Chao,Ma,Baode,Chen,Gen Qiang,et al. Highly efficient and enantioselective synthesis of β-heteroaryl amino alcohols via Ru-catalyzed asymmetric hydrogenation[J]. CHEMICAL COMMUNICATIONS,2022,31(17-19).
APA
Wu,Chao,Ma,Baode,Chen,Gen Qiang,&Zhang,Xumu.(2022).Highly efficient and enantioselective synthesis of β-heteroaryl amino alcohols via Ru-catalyzed asymmetric hydrogenation.CHEMICAL COMMUNICATIONS,31(17-19).
MLA
Wu,Chao,et al."Highly efficient and enantioselective synthesis of β-heteroaryl amino alcohols via Ru-catalyzed asymmetric hydrogenation".CHEMICAL COMMUNICATIONS 31.17-19(2022).
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