中文版 | English
Title

Dual targeting nanoparticles for epilepsy therapy

Author
Corresponding AuthorLu,Yi; Zheng,Wenfu; Jiang,Xingyu
Publication Years
2022
DOI
Source Title
ISSN
2041-6520
EISSN
2041-6539
Abstract
For epilepsy therapy, one-third of the patients worldwide are resistant to antiepileptic drugs mainly due to the existence of the blood-brain barrier (BBB) that prevents the drugs from reaching the epileptic lesions. Here, we design a double targeting nanoparticle carrying lamotrigine (LTG) to cross the BBB and further concentrate at the neurons. We prepare the nanoparticles on a microfluidic chip by encapsulating LTG in poly(lactic-co-glycolic acid) (PLGA) to form a core (PL) and capping the core with a shell of lipids conjugated with the D-T7 peptide (targeting the BBB) and Tet1 peptide (targeting the neuron) to form D-T7/Tet1-lipids@PL nanoparticles (NPs). In vitro and in vivo experiments show that D-T7/Tet1-lipids@PL NPs have excellent neuron targeting, antiepileptic, and protecting effects. Our approach provides a new strategy for improving the therapeutic efficacy of existing antiepileptic drugs.
URL[Source Record]
Indexed By
SCI ; EI
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
First ; Corresponding
Funding Project
National Key R&D Program of China["2021YFF1200800","2020YFA0908900","2018YFA0902600","2021YFF1200100"] ; National Natural Science Foundation of China["32071390","81730051"] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003] ; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009] ; Shenzhen Science and Technology Program[KQTD20190929172743294] ; Chinese Academy of Sciences[QYZDJ-SSW-SLH039] ; Shenzhen Bay Laboratory[SZBL2019062801004] ; Guangdong Innovative and Entrepreneurial Research Team Program[2019ZT08Y191]
WOS Research Area
Chemistry
WOS Subject
Chemistry, Multidisciplinary
WOS Accession No
WOS:000874887500001
Publisher
EI Accession Number
20224613121989
EI Keywords
Neurons ; Patient treatment ; Peptides
ESI Classification Code
Medicine and Pharmacology:461.6 ; Biology:461.9 ; Nanotechnology:761 ; Solid State Physics:933
Scopus EID
2-s2.0-85141868296
Data Source
Scopus
Citation statistics
Cited Times [WOS]:2
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/411860
DepartmentDepartment of Biomedical Engineering
Affiliation
1.Shenzhen Key Laboratory of Smart Healthcare Engineering,Guangdong Provincial Key Laboratory of Advanced Biomaterials,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,National Center for Nanoscience and Technology,Beijing,100190,China
3.Department of Chemistry,School of Science,Tianjin University,Tianjin,300350,China
4.CAS Key Laboratory of Brain Connectome and Manipulation,the Brain Cognition and Brain Disease Institute,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen,518055,China
First Author AffilicationDepartment of Biomedical Engineering
Corresponding Author AffilicationDepartment of Biomedical Engineering
First Author's First AffilicationDepartment of Biomedical Engineering
Recommended Citation
GB/T 7714
Hou,Qinghong,Wang,Lulu,Xiao,Feng,et al. Dual targeting nanoparticles for epilepsy therapy[J]. Chemical Science,2022.
APA
Hou,Qinghong.,Wang,Lulu.,Xiao,Feng.,Wang,Le.,Liu,Xiaoyan.,...&Jiang,Xingyu.(2022).Dual targeting nanoparticles for epilepsy therapy.Chemical Science.
MLA
Hou,Qinghong,et al."Dual targeting nanoparticles for epilepsy therapy".Chemical Science (2022).
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