中文版 | English
Title

In Vivo Imaging of Exosomes Labeled with NIR-II Polymer Dots in Liver-Injured Mice

Author
Corresponding AuthorMeng,Zihui
Publication Years
2022
DOI
Source Title
ISSN
1525-7797
EISSN
1526-4602
Abstract
Mesenchymal stem cell-derived exosomes (MSC-Exos) are emerging as a promising platform for treating various intractable diseases and organ injuries. Monitoring their migration, homing, and therapeutic capability in vivo is essential to develop exosome-based theranostics. Here, we designed fluorescent semiconductor polymer dots (Pdots) in the second near-infrared window (NIR-II) for bright labeling and tracking of MSC-Exos. Glucose-coated Pdots (Pdots-Glu) were able to label MSC-Exos without changing their biological properties. The NIR-II fluorescent Pdots allow for high labeling brightness and long-term in vivo tracking of MSC-Exos. We investigated the biodistributions and therapeutic functions of these labeled MSC-Exos in liver-resected mice. In vivo and ex vivo imaging demonstrated that the Pdot-labeled MSC-Exos injected via the tail vein mainly accumulated in the residual liver tissue. In terms of the therapeutic effect, MSC-Exos may accelerate postoperative liver function recovery by inhibiting inflammatory responses, promoting cell proliferation, and resisting apoptosis. Our results indicated that MSC-Exos therapeutic systems hold promising applications in liver regenerative medicine.
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
Funding Project
[20180201055YY]
WOS Research Area
Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS Subject
Biochemistry & Molecular Biology ; Chemistry, Organic ; Polymer Science
WOS Accession No
WOS:000878942500001
Publisher
ESI Research Field
BIOLOGY & BIOCHEMISTRY
Scopus EID
2-s2.0-85141644254
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/411881
DepartmentDepartment of Biomedical Engineering
Affiliation
1.Department of Hepatobiliary-Pancreatic Surgery,China-Japan Union Hospital,Jilin University,Changchun,Jilin,130000,China
2.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
Recommended Citation
GB/T 7714
Ma,Ning,Liu,Ye,Chen,Dandan,et al. In Vivo Imaging of Exosomes Labeled with NIR-II Polymer Dots in Liver-Injured Mice[J]. BIOMACROMOLECULES,2022.
APA
Ma,Ning,Liu,Ye,Chen,Dandan,Wu,Changfeng,&Meng,Zihui.(2022).In Vivo Imaging of Exosomes Labeled with NIR-II Polymer Dots in Liver-Injured Mice.BIOMACROMOLECULES.
MLA
Ma,Ning,et al."In Vivo Imaging of Exosomes Labeled with NIR-II Polymer Dots in Liver-Injured Mice".BIOMACROMOLECULES (2022).
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