Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways
|Corresponding Author||Yu，Zongyan; Xiao，Bo|
Myelin-forming oligodendrocytes in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS) are essential for structural and functional homeostasis of nervous tissue. Albeit with certain similarities, the regulation of CNS and PNS myelination is executed differently. Recent advances highlight the coordinated regulation of oligodendrocyte myelination by amino-acid sensing and growth factor signaling pathways. In this review, we discuss novel insights into the understanding of differential regulation of oligodendrocyte and Schwann cell biology in CNS and PNS myelination, with particular focus on the roles of growth factor-stimulated RHEB-mTORC1 and GATOR2-mediated amino-acid sensing/signaling pathways. We also discuss recent progress on the metabolic regulation of oligodendrocytes and Schwann cells and the impact of their dysfunction on neuronal function and disease.
First ; Corresponding
Shenzhen Innovation Committee of Science and Technology["ZDSYS20200811144002008","2019193984"] ; National Natural Science Foundation of China["31970773","31530042"] ; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions[2021SHIBS0002]
|WOS Research Area|
Neurosciences & Neurology
|WOS Accession No|
Cited Times [WOS]:1
|Document Type||Journal Article|
|Department||Department of Biology|
Shenzhen Key Laboratory of Gene Regulation and Systems Biology,Department of Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518000,China
|First Author Affilication||Department of Biology; School of Life Sciences|
|Corresponding Author Affilication||Department of Biology; School of Life Sciences|
|First Author's First Affilication||Department of Biology; School of Life Sciences|
Yang，Zhiwen,Yu，Zongyan,Xiao，Bo. Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways[J]. Neuroscience Bulletin,2022,39(3).
Yang，Zhiwen,Yu，Zongyan,&Xiao，Bo.(2022).Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways.Neuroscience Bulletin,39(3).
Yang，Zhiwen,et al."Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways".Neuroscience Bulletin 39.3(2022).
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