Miniature NIR-II Nanoprobes for Active-Targeted Phototheranostics of Brain Tumors
|Corresponding Author||Zheng，Hairong; Sheng，Zonghai|
Nanoprobes (NPs) in the second near-infrared biowindow (NIR-II, 1000–1700 nm) are developed and widely used in cancer phototheranostics. However, most NIR-II NPs exhibit low phototheranostic efficiency due to their tedious synthetic routes, large particle sizes (>20 nm), and lack of active targeting properties. Here, miniature NIR-II NPs, named HSA-ICG-iRGD, for active-targeted NIR-II phototheranostics of brain tumors are reported. The HSA-ICG-iRGD probes are designed based on hydrophobic interactions as well as hydrogen bonds between albumin and indocyanine green derivatives (ICG-iRGD) via molecular docking. The as-prepared NPs have a compact size of 10 nm and show tumor-targeting ability by specifically binding to αβ integrin receptors which are highly expressed on the surface of brain tumor cells via iRGD peptides. The HSA-ICG-iRGD NPs are then applied to perform active-targeted NIR-II fluorescence imaging, resulting in a signal-to-background ratio of 6.85 in orthotopic glioma mouse models. Under the selected laser irradiation of 808 nm, the photothermal effect of HSA-ICG-iRGD extends the survival of the tumor-bearing mice to 55 days, significantly longer than that of the control group (30 days). These results highlight the potential of miniature NPs for active-targeted NIR-II fluorescence imaging and phototherapy of brain tumors.
|WOS Accession No|
Cited Times [WOS]:1
|Document Type||Journal Article|
|Department||Department of Materials Science and Engineering|
1.Paul C. Lauterbur Research Center for Biomedical Imaging,Key Laboratory for Magnetic Resonance and Multimodality Imaging of Guangdong Province,Shenzhen Key Laboratory of Ultrasound Imaging and Therapy,CAS key laboratory of health informatics,Institute of Biomedical and Health Engineering,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,China
2.Department of Materials Science and Engineering,Shenzhen Key Laboratory of Printed Organic Electronics,Southern University of Science and Technology,Shenzhen,518055,China
Wu，Yayun,Hu，Dehong,Gao，Duyang,et al. Miniature NIR-II Nanoprobes for Active-Targeted Phototheranostics of Brain Tumors[J]. Advanced Healthcare Materials,2022.
Wu，Yayun,Hu，Dehong,Gao，Duyang,Liu，Chunchen,Zheng，Hairong,&Sheng，Zonghai.(2022).Miniature NIR-II Nanoprobes for Active-Targeted Phototheranostics of Brain Tumors.Advanced Healthcare Materials.
Wu，Yayun,et al."Miniature NIR-II Nanoprobes for Active-Targeted Phototheranostics of Brain Tumors".Advanced Healthcare Materials (2022).
|Files in This Item:||There are no files associated with this item.|
|Recommend this item|
|Export to Endnote|
|Export to Excel|
|Export to Csv|
|Similar articles in Google Scholar|
|Similar articles in Baidu Scholar|
|Similar articles in Bing Scholar|
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.