中文版 | English
Title

ACE2, B0AT1, and SARS-CoV-2 spike protein: Structural and functional implications

Author
Corresponding AuthorRenhong,Yan; Qiang,Zhou
Publication Years
2022-06-17
DOI
Source Title
ISSN
0959-440X
EISSN
1879-033X
Volume74Pages:102388
Abstract

The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as a public health crisis and led to tremendous economic devastation. The spike protein (S) of SARS-CoV-2 hijacks the angiotensin converting enzyme 2 (ACE2) as a receptor for virus entry, representing the initial step of viral infection. S is one of the major targets for development of the antiviral drugs, antibodies, and vaccines. ACE2 is a peptidase that plays a physiologically important role in the renin-angiotensin system. Concurrently, it also forms dimer of heterodimer with the neutral amino acid transporter B(0)AT1 to regulate intestinal amino acid metabolism. The symptoms of COVID-19 are closely correlated with the physiological functions of ACE2. In this review, we summarize the functional and structural studies on ACE2, B(0)AT1, and their complex with S of SARS-CoV-2, providing insights into the various symptoms caused by viral infection and the development of therapeutic strategies.

Keywords
Subject Area
生物化学
Degree Discipline
理学::生物学
URL[Source Record]
Indexed By
SCI ; EI ; ESCI
Language
English
SUSTech Authorship
Corresponding
WOS Accession No
WOS:000829029500015
Publisher
ESI Research Field
BIOLOGY & BIOCHEMISTRY
Data Source
人工提交
Year
2022
PDF url
ACE2, B0AT1, and SARS-CoV-2 spike protein: Structural and functional implications - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108414/
Publication Status
在线出版
Citation statistics
Cited Times [WOS]:3
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/411962
DepartmentDepartment of Biochemistry
南方科技大学医学院
理学院_化学系
Affiliation
1.Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China
2.Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China
3.Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China
Corresponding Author AffilicationDepartment of Biochemistry;  School of Medicine
Recommended Citation
GB/T 7714
Yuanyuan,Zhang,Renhong,Yan,Qiang,Zhou. ACE2, B0AT1, and SARS-CoV-2 spike protein: Structural and functional implications[J]. CURRENT OPINION IN STRUCTURAL BIOLOGY,2022,74:102388.
APA
Yuanyuan,Zhang,Renhong,Yan,&Qiang,Zhou.(2022).ACE2, B0AT1, and SARS-CoV-2 spike protein: Structural and functional implications.CURRENT OPINION IN STRUCTURAL BIOLOGY,74,102388.
MLA
Yuanyuan,Zhang,et al."ACE2, B0AT1, and SARS-CoV-2 spike protein: Structural and functional implications".CURRENT OPINION IN STRUCTURAL BIOLOGY 74(2022):102388.
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