Recent Advances in Animal Models, Diagnosis, and Treatment of Temporomandibular Joint Osteoarthritis

Wang, Dongyun1; Qi, Yajie1,2; Wang, Zhubing3; Guo, Anyun4; Xu, Yingxin1,5; Zhang, Yang3,6

2022-10-01

10.1089/ten.teb.2022.0065

Tissue Engineering Part B-Reviews   Impact Factor & Quartile

1937-3368

1937-3376

Temporomandibular joint osteoarthritis (TMJOA) is a gradual degenerative jaw joint condition. Until recent years, TMJOA is still relatively unrecognized and ineffective to be treated. Appropriate animal models with reliable detection methods can help researchers understand the pathophysiology of TMJOA and find therapeutic options. In this study, we summarized common animal models of TMJOA created by chemical, surgical, mechanical, and genetical approaches. The relevant pathological symptoms and induction mechanisms were outlined. In addition, different pathological indicators, furthermore, emerging therapeutic regimens, such as intra-articular drug delivery and tissue engineering-based approaches to treat TMJOA based on these animal models, were summarized and updated. Understanding the physiology and pathogenesis of the TMJOA, together using various ways to diagnose the TMJOA, were elaborated, including imaging techniques, molecular techniques for detecting inflammatory cytokines, histochemical staining, and histomorphometry measures. A more reliable diagnosis will enable the development of new prevention and more effective treatment strategies and thereby improve the quality of life of TMJOA patients. Impact statementTemporomandibular joint osteoarthritis (TMJOA) affects 8 to 16 percent of the population worldwide. However, TMJOA is still relatively unrecognized and ineffective to be treated in the clinic. Appropriate animal models with reliable diagnostic methods can help researchers understand the pathophysiology of TMJOA and find therapeutic options. We herein summarized common animal models of TMJOA and various ways to diagnose the TMJOA. More importantly, emerging therapeutic regimens to treat TMJOA based on these animal models were summarized. With the aid of strategies listed, more effective treatment strategies will be developed and thereby improve the life quality of TMJOA patients.

temporomandibular joint osteoarthritis animal model diagnose treatment new methods

SCI

English

Others

Shenzhen Science and Technology Innovation Committee["JCYJ20190808152211686","JCYJ20190808120217133","JCYJ202103241-05408022"] ; Sanming Project of Medicine in Shenzhen[SZSM202111012] ; Shenzhen University[JG2021169]

Cell Biology ; Biotechnology & Applied Microbiology ; Engineering ; Materials Science

Cell & Tissue Engineering ; Biotechnology & Applied Microbiology ; Cell Biology ; Engineering, Biomedical ; Materials Science, Biomaterials

WOS:000875313100001

MARY ANN LIEBERT, INC

Web of Science

1.Peking Univ Shenzhen Hosp, Stomatol Ctr, Guangdong Prov Engn Res Ctr Oral Dis Diag & Treatm, Guangdong Prov High level Clin Key Specialty, Shenzhen, Peoples R China
2.Clin Coll Anhui Med Univ, Peking Univ Shenzhen Hosp, Shenzhen, Peoples R China
3.Shenzhen Univ, Hlth Sci Ctr, Sch Dent, Shenzhen, Peoples R China
4.Southern Univ Sci & Technol Hosp, Dept Joint Surg, Shenzhen, Peoples R China
5.Peking Univ Shenzhen Hosp, Stomatol Ctr, Guangdong Prov High level Clin Key Speciality, Guangdong Prov Engn Res Ctr Oral Dis Diagnosis & T, 1120 Lianhua Rd, Shenzhen 518036, Peoples R China
6.Shenzhen Univ, Sch Dent Hlth Sci Ctr, 1066 Xueyuan Rd, Shenzhen 518060, Peoples R China

Wang, Dongyun,Qi, Yajie,Wang, Zhubing,et al. Recent Advances in Animal Models, Diagnosis, and Treatment of Temporomandibular Joint Osteoarthritis[J]. Tissue Engineering Part B-Reviews,2022.

Wang, Dongyun,Qi, Yajie,Wang, Zhubing,Guo, Anyun,Xu, Yingxin,&Zhang, Yang.(2022).Recent Advances in Animal Models, Diagnosis, and Treatment of Temporomandibular Joint Osteoarthritis.Tissue Engineering Part B-Reviews.

Wang, Dongyun,et al."Recent Advances in Animal Models, Diagnosis, and Treatment of Temporomandibular Joint Osteoarthritis".Tissue Engineering Part B-Reviews (2022).