Title | Preparation of Chiral gamma-Secondary Amino Alcohols via Ni-Catalyzed Asymmetric Reductive Coupling of 2-Aza-butadiene with Aldehydes |
Author | |
Corresponding Author | Zhang, Li; Zhang, Xia |
Publication Years | 2022-10-01
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DOI | |
Source Title | |
ISSN | 1523-7060
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EISSN | 1523-7052
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Abstract | The first Ni-catalyzed asymmetric reductive coupling of 2-aza-butadiene with aldehydes was achieved to synthesize chiral gamma- secondary amino alcohols. This transformation features good enantioselectivity and tolerance to various functional groups, which may serve as a complementary method to previously reported noble-metal-catalyzed protocols. Through competition reaction, 2-aza-butadiene was proved to be a more reactive coupling component than its full-carbon analogue, 1,3-butadiene. Notably, this reaction delivers beta-siloxyl imine, an aza-aldol-type product which is difficult to access by conventional methods. |
URL | [Source Record] |
Indexed By | |
Language | English
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Important Publications | NI Journal Papers
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SUSTech Authorship | Others
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Funding Project | [81803359]
; [21907071]
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WOS Research Area | Chemistry
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WOS Subject | Chemistry, Organic
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WOS Accession No | WOS:000874421300001
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Publisher | |
ESI Research Field | CHEMISTRY
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Data Source | Web of Science
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Citation statistics |
Cited Times [WOS]:1
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/412131 |
Department | Shenzhen Grubbs Institute 理学院_化学系 |
Affiliation | 1.Sichuan Univ, West China Hosp, Inst Resp Hlth, Dept Resp & Crit Care Med,State Key Lab Biotherapy, Chengdu 610041, Peoples R China 2.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518000, Peoples R China 3.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518000, Peoples R China |
First Author Affilication | Shenzhen Grubbs Institute; Department of Chemistry |
Recommended Citation GB/T 7714 |
Yang, Lei,Shang, Weidong,Zhang, Li,et al. Preparation of Chiral gamma-Secondary Amino Alcohols via Ni-Catalyzed Asymmetric Reductive Coupling of 2-Aza-butadiene with Aldehydes[J]. ORGANIC LETTERS,2022.
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APA |
Yang, Lei,Shang, Weidong,Zhang, Li,&Zhang, Xia.(2022).Preparation of Chiral gamma-Secondary Amino Alcohols via Ni-Catalyzed Asymmetric Reductive Coupling of 2-Aza-butadiene with Aldehydes.ORGANIC LETTERS.
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MLA |
Yang, Lei,et al."Preparation of Chiral gamma-Secondary Amino Alcohols via Ni-Catalyzed Asymmetric Reductive Coupling of 2-Aza-butadiene with Aldehydes".ORGANIC LETTERS (2022).
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