中文版 | English
Title

Preparation of Chiral gamma-Secondary Amino Alcohols via Ni-Catalyzed Asymmetric Reductive Coupling of 2-Aza-butadiene with Aldehydes

Author
Corresponding AuthorZhang, Li; Zhang, Xia
Publication Years
2022-10-01
DOI
Source Title
ISSN
1523-7060
EISSN
1523-7052
Abstract
The first Ni-catalyzed asymmetric reductive coupling of 2-aza-butadiene with aldehydes was achieved to synthesize chiral gamma- secondary amino alcohols. This transformation features good enantioselectivity and tolerance to various functional groups, which may serve as a complementary method to previously reported noble-metal-catalyzed protocols. Through competition reaction, 2-aza-butadiene was proved to be a more reactive coupling component than its full-carbon analogue, 1,3-butadiene. Notably, this reaction delivers beta-siloxyl imine, an aza-aldol-type product which is difficult to access by conventional methods.
URL[Source Record]
Indexed By
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
Others
Funding Project
[81803359] ; [21907071]
WOS Research Area
Chemistry
WOS Subject
Chemistry, Organic
WOS Accession No
WOS:000874421300001
Publisher
ESI Research Field
CHEMISTRY
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/412131
DepartmentShenzhen Grubbs Institute
理学院_化学系
Affiliation
1.Sichuan Univ, West China Hosp, Inst Resp Hlth, Dept Resp & Crit Care Med,State Key Lab Biotherapy, Chengdu 610041, Peoples R China
2.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518000, Peoples R China
3.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518000, Peoples R China
First Author AffilicationShenzhen Grubbs Institute;  Department of Chemistry
Recommended Citation
GB/T 7714
Yang, Lei,Shang, Weidong,Zhang, Li,et al. Preparation of Chiral gamma-Secondary Amino Alcohols via Ni-Catalyzed Asymmetric Reductive Coupling of 2-Aza-butadiene with Aldehydes[J]. ORGANIC LETTERS,2022.
APA
Yang, Lei,Shang, Weidong,Zhang, Li,&Zhang, Xia.(2022).Preparation of Chiral gamma-Secondary Amino Alcohols via Ni-Catalyzed Asymmetric Reductive Coupling of 2-Aza-butadiene with Aldehydes.ORGANIC LETTERS.
MLA
Yang, Lei,et al."Preparation of Chiral gamma-Secondary Amino Alcohols via Ni-Catalyzed Asymmetric Reductive Coupling of 2-Aza-butadiene with Aldehydes".ORGANIC LETTERS (2022).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Export to Excel
Export to Csv
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Yang, Lei]'s Articles
[Shang, Weidong]'s Articles
[Zhang, Li]'s Articles
Baidu Scholar
Similar articles in Baidu Scholar
[Yang, Lei]'s Articles
[Shang, Weidong]'s Articles
[Zhang, Li]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, Lei]'s Articles
[Shang, Weidong]'s Articles
[Zhang, Li]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.