Title | Small Molecular Inhibitors Reverse Cancer Metastasis by Blockading Oncogenic PITPNM3 |
Author | |
Corresponding Author | Xu, Xiaoding; Song, Erwei; Gong, Chang |
Publication Years | 2022-10-01
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DOI | |
Source Title | |
EISSN | 2198-3844
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Abstract | Most cancer-related deaths are a result of metastasis. The development of small molecular inhibitors reversing cancer metastasis represents a promising therapeutic opportunity for cancer patients. This pan-cancer analysis identifies oncogenic roles of membrane-associated phosphatidylinositol transfer protein 3 (PITPNM3), which is crucial for cancer metastasis. Small molecules targeting PITPNM3 must be explored further. Here, PITPNM3-selective small molecular inhibitors are reported. These compounds exhibit target-specific inhibition of PITPNM3 signaling, thereby reducing metastasis of breast cancer cells. Besides, by using nanoparticle-based delivery systems, these PITPNM3-selective compounds loaded nanoparticles significantly repress metastasis of breast cancer in mouse xenograft models and organoid models. Notably, the results establish an important metastatic-promoting role for PITPNM3 and offer PITPNM3 inhibition as a therapeutic strategy in metastatic breast cancer. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
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SUSTech Authorship | Others
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Funding Project | Natural Science Foundation of China["81621004","92159303","81720108029","81930081","91940305","81872139","82072907"]
; Beijing Xisike Clinical Oncology Research Foundation["Y-Roche2019/2-0078","Y-pierrefabre202102-0107"]
; Technology Development Program of Guangdong province[2021A0505030082]
; Guangdong Science and Technology Department["2020B1212060018","2020B1212030004"]
; Project of The Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation[2020B1212060018]
; Department of Natural Resources of Guangdong Province[GDNRC[2021]51]
; Bureau of Science and Technology of Guangzhou[20212200003]
; Program for Guangdong Introducing Innovative and Enterpreneurial Teams[2019BT02Y198]
; Clinical Innovation Research Program of Bioland Laboratory[2018GZR0201004]
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WOS Research Area | Chemistry
; Science & Technology - Other Topics
; Materials Science
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WOS Subject | Chemistry, Multidisciplinary
; Nanoscience & Nanotechnology
; Materials Science, Multidisciplinary
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WOS Accession No | WOS:000871902400001
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Publisher | |
Data Source | Web of Science
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Citation statistics |
Cited Times [WOS]:0
|
Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/412135 |
Department | Shenzhen People's Hospital |
Affiliation | 1.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Breast Tumor Ctr, Guangzhou 510120, Peoples R China 2.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou 510120, Peoples R China 3.Cardiff Univ, Sch Med, Cardiff China Med Res Collaborat, Heath Pk, Cardiff CF14 4XN, Wales 4.Sun Yat Sen Univ, Zhongshan Sch Med, Dept Biochem, Guangzhou 510080, Peoples R China 5.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Pharm, Guangzhou 510120, Peoples R China 6.Southern Univ Sci & Technol, Affiliated Hosp 1, Jinan Univ, Clin Med Coll 2,Dept Breast & Thyroid Surg,Shenzh, Shenzhen 518020, Peoples R China |
First Author Affilication | Shenzhen People's Hospital |
Recommended Citation GB/T 7714 |
Liu, Zihao,Shi, Yu,Lv, Li,et al. Small Molecular Inhibitors Reverse Cancer Metastasis by Blockading Oncogenic PITPNM3[J]. ADVANCED SCIENCE,2022.
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APA |
Liu, Zihao.,Shi, Yu.,Lv, Li.,Chen, Jianing.,Jiang, WenG.,...&Gong, Chang.(2022).Small Molecular Inhibitors Reverse Cancer Metastasis by Blockading Oncogenic PITPNM3.ADVANCED SCIENCE.
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MLA |
Liu, Zihao,et al."Small Molecular Inhibitors Reverse Cancer Metastasis by Blockading Oncogenic PITPNM3".ADVANCED SCIENCE (2022).
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