Sonodynamic Therapy with Concentric Ultrasound Imaging Array for Precision Theranostics for Atherosclerotic Plaque

Shuo Wang1; Zeping Gao2; Ye Yang2; Qi Zhang2; Jiqing Huang2; Bing Wang1; Shuang Lei2; Qingyuan Tan2; Dingyuan Liu1; Lunhuang Guo2; Yuting Song2; Jiamei Liu2; Teng Ma2; Ye Tian3

2022

10.1109/TUFFC.2022.3215436

IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control   Impact Factor & Quartile

1525-8955

1525-8955

Atherosclerotic cardiovascular disease is a major cause of human disability and mortality. Our previous study demonstrated the safety and efficacy of sonodynamic therapy (SDT) on atherosclerotic plaques. However, traditional single-element therapeutic transducer has single acoustic field, and positioning therapeutic and imaging transducers in the same position is difficult during ultrasound imaging-guided SDT. Continuously changing the position of transducers to intervene lesions in different positions is required, increasing the difficulty of treatment. Thus, an SDT device with precise theranostics is required. Therefore, we designed and fabricated a "concentric ultrasound transducer for theranostics " (CUST-T), comprising a central 8-MHz linear array transducer for ultrasound imaging, and a peripheral 1-MHz hollow two-dimensional (2-D) planar array transducer for generating phased-array focused ultrasound (PAFUS). The CUST-T exhibited high imaging resolution at a distance of up to 20 mm from the transducer and could generate a personalized complex PAFUS acoustic field to match various lesions. In vitro biomedical results showed that PAFUS-SDT induced RAW264.7-derived foam cell apoptosis leading to a targeting field apoptotic rate 4.36-6.24 times that of the nontargeting field and the significant apoptotic region was consistent with the PAFUS acoustic field. In vivo, PAFUS-SDT guided by ultrasound imaging significantly increased the lumen area ( ${P} < 0.05$ ) and collagen level ( ${P} < 0.01$ ), whereas the wall thickness ( ${P} < 0.05$ ) and lipid content ( ${P} < 0.01$ ) of rabbit femoral artery were reduced. In conclusion, CUST-T provided image guidance sufficient for accurate SDT for atherosclerotic plaques in peripheral arteries and could be applied in clinical practice.

Sonodynamic therapy Atherosclerosis Phased-array focused ultrasound Ultrasonic imaging Concentric ultrasonic transducer

SCI

English

Others

National Natural Science Foundation of China["81727809","81530052"]

Acoustics ; Engineering

Acoustics ; Engineering, Electrical & Electronic

WOS:000890883600005

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC

IEEE

1.Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
2.Shenzhen Institutes of Advanced Technology, Institute of Biomedical and Health Engineering, Chinese Academy of Sciences, Shenzhen, China
3.Second Affiliated Hospital of Southern University of Science and Technology (The Third People’s Hospital of Shenzhen), Southern University of Science and Technology, Shenzhen, China

Shuo Wang,Zeping Gao,Ye Yang,et al. Sonodynamic Therapy with Concentric Ultrasound Imaging Array for Precision Theranostics for Atherosclerotic Plaque[J]. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control,2022,PP(99):1-1.

Shuo Wang.,Zeping Gao.,Ye Yang.,Qi Zhang.,Jiqing Huang.,...&Ye Tian.(2022).Sonodynamic Therapy with Concentric Ultrasound Imaging Array for Precision Theranostics for Atherosclerotic Plaque.IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control,PP(99),1-1.

Shuo Wang,et al."Sonodynamic Therapy with Concentric Ultrasound Imaging Array for Precision Theranostics for Atherosclerotic Plaque".IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control PP.99(2022):1-1.