中文版 | English
Title

Strontium-modified porous polyetheretherketone with the triple function of osteogenesis, angiogenesis, and anti-inflammatory for bone grafting

Author
Corresponding AuthorWang, Ning; Tang, Bin
Publication Years
2022-12-01
DOI
Source Title
EISSN
2772-9508
Volume143
Abstract
Polyetheretherketone (PEEK) is a potential bone repair material because of its stable chemical and good me-chanical properties. However, the biological inertness of PEEK limits its clinical application. Sr2+ has multi biological functions, including promoting bone formation and blood vessel regeneration and inhibiting inflam-mation. In this paper, PEEK was modified with Sr2+ with the purpose to construct PEEK bone graft material with triple functions of osteogenesis, angiogenesis, and anti-inflammatory. The results showed that Sr-modified PEEK could stably release Sr2+ for a long time in the PBS solution, and indeed could promote the proliferation and differentiation of osteoblasts, promote angiogenesis, and inhibit inflammation. Therefore, it is believed that this multifunctional PEEK with Sr2+ should show great promise for clinical applications in bone repair.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
First ; Corresponding
Funding Project
[2019YFA0906004] ; [11872200] ; [JSGG20200225151916021] ; [JSSCBS20210911]
WOS Research Area
Materials Science
WOS Subject
Materials Science, Biomaterials
WOS Accession No
WOS:000883917000004
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/412190
DepartmentDepartment of Biomedical Engineering
南方科技大学医院
Affiliation
1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China
2.Univ Hong Kong, Dept Mech Engn, Pokfulam, Hong Kong, Peoples R China
3.Jiangsu Univ Technol, Sch Chem & Environm Engn, Changzhou 213001, Jiangsu, Peoples R China
4.Southern Univ Sci & Technol Hosp, Smart Biomat Design Lab, Shenzhen 518055, Guangdong, Peoples R China
5.Shenzhen Technol Univ, Coll New Mat & New Energies, Shenzhen 518055, Guangdong, Peoples R China
First Author AffilicationDepartment of Biomedical Engineering
Corresponding Author AffilicationDepartment of Biomedical Engineering
First Author's First AffilicationDepartment of Biomedical Engineering
Recommended Citation
GB/T 7714
Hu, Liqiu,Ge, Yongmei,Cao, Zhe,et al. Strontium-modified porous polyetheretherketone with the triple function of osteogenesis, angiogenesis, and anti-inflammatory for bone grafting[J]. BIOMATERIALS ADVANCES,2022,143.
APA
Hu, Liqiu.,Ge, Yongmei.,Cao, Zhe.,Tian, Ye.,Sun, QiLi.,...&Tang, Bin.(2022).Strontium-modified porous polyetheretherketone with the triple function of osteogenesis, angiogenesis, and anti-inflammatory for bone grafting.BIOMATERIALS ADVANCES,143.
MLA
Hu, Liqiu,et al."Strontium-modified porous polyetheretherketone with the triple function of osteogenesis, angiogenesis, and anti-inflammatory for bone grafting".BIOMATERIALS ADVANCES 143(2022).
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