南方科技大学知识苑(SUSTech KC): Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells

Title	Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells
Author	Zhang, Ying 1; Zhang, Qianyu 3; Chu, Zheng 1,2; Chen, Lin 1,2; Chen, Jiayun 1,2; Yang, Yang 1,2; Tang, Huan 1,2; Cheng, Guangqing 1,2; Ma, Ang 1,2; Wang, Chen 1,2; Gao, Peng 1,2; Xia, Fei 1,2; Guo, Qiuyan 1,2; Shi, Qiaoli 1,2; Han, Guang 3; Wang, Jigang 1,2,4; Zhu, Yinhua 1,2
Corresponding Author	Han, Guang; Wang, Jigang; Zhu, Yinhua
Publication Years	2022-10-01
DOI	10.1039/d2cc05278d
Source Title	CHEMICAL COMMUNICATIONS Impact Factor & Quartile
ISSN	1359-7345
EISSN	1364-548X
Abstract	Most of the known senolytics are anti-cancer drugs or their derivative molecules. However, senolytics derived from the active ingredients of traditional Chinese medicine (TCM) are rarely reported. Here, we identified oridonin as a novel senolytic and further revealed that it might target a class of glutathione S-transferases to activate ROS-p38 signaling and induce apoptosis in senescent cells.
URL	[Source Record]
Indexed By	SCI
Language	English
Important Publications	NI Journal Papers
SUSTech Authorship	Corresponding
Funding Project	National Key Research and Development Program of China[2020YFA0908000] ; Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine[ZYYCXTD-C-202002] ; National Key R&D Program of China Key projects for international cooperation on science, technology and innovation[2020YFE0205100] ; CACMS Innovation Fund["CI2021A05101","CI2021A05104"] ; Fundamental Research Funds for the Central public welfare research institutes[ZZ15-YQ-062] ; National Natural Science Foundation of China["82074098","81841001","82274182"]
WOS Research Area	Chemistry
WOS Subject	Chemistry, Multidisciplinary
WOS Accession No	WOS:000883803700001
Publisher	ROYAL SOC CHEMISTRY
ESI Research Field	CHEMISTRY
Data Source	Web of Science
Citation statistics	Cited Times [WOS]:1
Document Type	Journal Article
Identifier	http://kc.sustech.edu.cn/handle/2SGJ60CL/412197
Department	Shenzhen People's Hospital
Affiliation	1.China Acad Chinese Med Sci, Artemisinin Res Cente, Beijing 100700, Peoples R China 2.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China 3.Henan Univ, Pharmaceut Coll, Kaifeng 75004, Peoples R China 4.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Dept Nephrol, Shenzhen 518020, Guangdong, Peoples R China
Corresponding Author Affilication	Shenzhen People's Hospital
Recommended Citation GB/T 7714	Zhang, Ying,Zhang, Qianyu,Chu, Zheng,et al. Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells[J]. CHEMICAL COMMUNICATIONS,2022.
APA	Zhang, Ying.,Zhang, Qianyu.,Chu, Zheng.,Chen, Lin.,Chen, Jiayun.,...&Zhu, Yinhua.(2022).Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells.CHEMICAL COMMUNICATIONS.
MLA	Zhang, Ying,et al."Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells".CHEMICAL COMMUNICATIONS (2022).

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