中文版 | English
Title

Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells

Author
Corresponding AuthorHan, Guang; Wang, Jigang; Zhu, Yinhua
Publication Years
2022-10-01
DOI
Source Title
ISSN
1359-7345
EISSN
1364-548X
Abstract
Most of the known senolytics are anti-cancer drugs or their derivative molecules. However, senolytics derived from the active ingredients of traditional Chinese medicine (TCM) are rarely reported. Here, we identified oridonin as a novel senolytic and further revealed that it might target a class of glutathione S-transferases to activate ROS-p38 signaling and induce apoptosis in senescent cells.
URL[Source Record]
Indexed By
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
Corresponding
Funding Project
National Key Research and Development Program of China[2020YFA0908000] ; Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine[ZYYCXTD-C-202002] ; National Key R&D Program of China Key projects for international cooperation on science, technology and innovation[2020YFE0205100] ; CACMS Innovation Fund["CI2021A05101","CI2021A05104"] ; Fundamental Research Funds for the Central public welfare research institutes[ZZ15-YQ-062] ; National Natural Science Foundation of China["82074098","81841001","82274182"]
WOS Research Area
Chemistry
WOS Subject
Chemistry, Multidisciplinary
WOS Accession No
WOS:000883803700001
Publisher
ESI Research Field
CHEMISTRY
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/412197
DepartmentShenzhen People's Hospital
Affiliation
1.China Acad Chinese Med Sci, Artemisinin Res Cente, Beijing 100700, Peoples R China
2.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China
3.Henan Univ, Pharmaceut Coll, Kaifeng 75004, Peoples R China
4.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Dept Nephrol, Shenzhen 518020, Guangdong, Peoples R China
Corresponding Author AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Zhang, Ying,Zhang, Qianyu,Chu, Zheng,et al. Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells[J]. CHEMICAL COMMUNICATIONS,2022.
APA
Zhang, Ying.,Zhang, Qianyu.,Chu, Zheng.,Chen, Lin.,Chen, Jiayun.,...&Zhu, Yinhua.(2022).Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells.CHEMICAL COMMUNICATIONS.
MLA
Zhang, Ying,et al."Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells".CHEMICAL COMMUNICATIONS (2022).
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