中文版 | English
Title

Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections

Author
Corresponding AuthorJu,Bin; Zhang,Zheng
Publication Years
2022-12-01
DOI
Source Title
EISSN
2041-1723
Volume13Issue:1
Abstract
With declining SARS-CoV-2-specific antibody titers and increasing numbers of spike mutations, the ongoing emergence of Omicron subvariants causes serious challenges to current vaccination strategies. BA.2 breakthrough infections have occurred in people who have received the wild-type vaccines, including mRNA, inactivated, or recombinant protein vaccines. Here, we evaluate the antibody evasion of recently emerged subvariants BA.4/5 and BA.2.75 in two inactivated vaccine-immunized cohorts with BA.2 breakthrough infections. Compared with the neutralizing antibody titers against BA.2, marked reductions are observed against BA.2.75 in both 2-dose and 3-dose vaccine groups. In addition, although BA.2 breakthrough infections induce a certain cross-neutralization capacity against later Omicron subvariants, the original antigenic sin phenomenon largely limits the improvement of variant-specific antibody response. These findings suggest that BA.2 breakthrough infections seem unable to provide sufficient antibody protection against later subvariants such as BA.2.75 in the current immunization background with wild-type vaccines.
URL[Source Record]
Indexed By
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
Corresponding
Funding Project
National Science Fund for Distinguished Young Scholars[82025022] ; National Natural Science Foundation of China["92169204","82002140","82171752"] ; China Postdoctoral Science Foundation[2021M703445] ; Guangdong Basic and Applied Basic Research Foundation["2021B1515020034","2019A1515011197"] ; Shenzhen Science and Technology Program["RCYX20200714114700046","RCBS20210706092345028"] ; Science and Technology Innovation Committee of Shenzhen Municipality["JSGG20220226085550001","JSGG20200207155251653","JSGG20200807171401008","JSGG20210901145200002"] ; Shenzhen Natural Science Foundation["JCYJ20190809115617365","JCYJ20200109144201725"]
WOS Research Area
Science & Technology - Other Topics
WOS Subject
Multidisciplinary Sciences
WOS Accession No
WOS:000886221900012
Publisher
Scopus EID
2-s2.0-85142293505
Data Source
Scopus
Citation statistics
Cited Times [WOS]:7
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/412549
DepartmentSchool of Medicine
南方科技大学第二附属医院
Affiliation
1.Institute for Hepatology,National Clinical Research Center for Infectious Disease,Shenzhen Third People’s Hospital,Shenzhen,Guangdong Province,518112,China
2.The Second Affiliated Hospital,School of Medicine,Southern University of Science and Technology,Shenzhen,Guangdong Province,518112,China
3.Guangdong Key Laboratory for Anti-infection Drug Quality Evaluation,Shenzhen,Guangdong Province,518112,China
4.Shenzhen Research Center for Communicable Disease Diagnosis and Treatment of Chinese Academy of Medical Science,Shenzhen,Guangdong Province,518112,China
First Author AffilicationSchool of Medicine;  The Third People's Hospital of Shenzhen
Corresponding Author AffilicationSchool of Medicine;  The Third People's Hospital of Shenzhen
Recommended Citation
GB/T 7714
Ju,Bin,Fan,Qing,Wang,Miao,et al. Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections[J]. Nature Communications,2022,13(1).
APA
Ju,Bin.,Fan,Qing.,Wang,Miao.,Liao,Xuejiao.,Guo,Huimin.,...&Zhang,Zheng.(2022).Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections.Nature Communications,13(1).
MLA
Ju,Bin,et al."Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections".Nature Communications 13.1(2022).
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