Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study
|Corresponding Author||Chen，Rongchang; He，Jianxing|
Background: Cytomegalovirus (CMV) infection is a leading cause of morbidity and mortality after transplantation. This study aimed to investigate CMV seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients. Methods: The clinical data of the patients who underwent lung and/or heart transplantation between January 2015 and October 2020 were retrospectively collected from four transplantation centers in China. Results: A total of 308 patients were analyzed. The CMV serostatus was donor positive (D) recipient negative (R) in 19 (6.17%) patients, D/R in 233 (75.65%), D/R in 36 (11.69%), and D/R in 20 (6.50%). CMV DNAemia was detected in 52.3% of the patients and tissue-invasive CMV disease was diagnosed in 16.2% of the patients. Only 31.8% of the patients adhered to the postdischarge valganciclovir therapy. The D/R serostatus (odds ratio [OR]: 18.32; 95% confidence interval [CI]:1.80-188.68), no valganciclovir prophylaxis (OR: 2.64; 95% CI: 1.05–6.64), and higher doses of rabbit anti-human thymocyte globulin (> 2 mg/kg) (OR: 4.25; 95% CI: 1.92–9.42) were risk factors of CMV disease. Conclusion: CMV seroprevalence was high in Chinese thoracic organ transplant donors and recipients. The low adherence rate to the postdischarge CMV prophylaxis therapy in Chinese patients is still an unresolved issue.
Natural Science Foundation of Guangdong Province[2018A030313107];State Key Laboratory of Respiratory Disease[SKLRD-QN-201710];
|WOS Research Area|
|WOS Accession No|
Cited Times [WOS]:0
|Document Type||Journal Article|
|Department||The Third People's Hospital of Shenzhen|
1.Guangzhou Institute of Respiratory Health,First Affiliated Hospital of Guangzhou Medical University,Guangzhou,Yanjiang Road,China
2.Department of Thoracic Surgery and Lung Transplantation,Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai,China
3.Department of Thoracic Surgery,The People’s Hospital of Gaozhou,Gaozhou,China
4.Shenzhen People’s Hospital Institute of Respiratory Diseases,Southern University of Science and Technology,University of Jinan Second Clinical Medical College,Shenzhen,East of Shennan Road, Luohu District,China
|Corresponding Author Affilication||Southern University of Science and Technology|
Ju，Chunrong,Wang，Xiaohua,Xu，Xin,et al. Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study[J]. BMC Infectious Diseases,2022,22(1).
Ju，Chunrong.,Wang，Xiaohua.,Xu，Xin.,Xie，Shaobo.,Cao，Qingdong.,...&He，Jianxing.(2022).Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study.BMC Infectious Diseases,22(1).
Ju，Chunrong,et al."Cytomegalovirus seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients: a retrospective cohort study".BMC Infectious Diseases 22.1(2022).
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