| Title | A microbial transporter of the dietary antioxidant ergothioneine |
| Author | Dumitrescu，Daniel G.1,2,3; Gordon，Elizabeth M.1,3; Kovalyova，Yekaterina1,2,3; Seminara，Anna B.1,3,4; Duncan-Lowey，Brianna5,6; Forster，Emily R.7,8; Zhou，Wen9  ; Booth，Carmen J.10; Shen，Aimee7; Kranzusch，Philip J.5,6,11; Hatzios，Stavroula K.1,2,3 ; Dumitrescu，Daniel G.12,13,14; Gordon，Elizabeth M.12,14; Kovalyova，Yekaterina12,13,14; Seminara，Anna B.12,14,15; Duncan-Lowey，Brianna16,17; Forster，Emily R.18,19; Zhou，Wen20; Booth，Carmen J.21; Shen，Aimee18; Kranzusch，Philip J.16,17,22; Hatzios，Stavroula K.12,13,14
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| Corresponding Author | Hatzios，Stavroula K.; Hatzios，Stavroula K. |
| Publication Years | 2022-11-23
|
| DOI | |
| Source Title | |
| ISSN | 0092-8674
|
| EISSN | 1097-4172
|
| Volume | 185Issue:24Pages:4526-4540.e18 |
| Abstract | Low-molecular-weight (LMW) thiols are small-molecule antioxidants required for the maintenance of intracellular redox homeostasis. However, many host-associated microbes, including the gastric pathogen Helicobacter pylori, unexpectedly lack LMW-thiol biosynthetic pathways. Using reactivity-guided metabolomics, we identified the unusual LMW thiol ergothioneine (EGT) in H. pylori. Dietary EGT accumulates to millimolar levels in human tissues and has been broadly implicated in mitigating disease risk. Although certain microorganisms synthesize EGT, we discovered that H. pylori acquires this LMW thiol from the host environment using a highly selective ATP-binding cassette transporter—EgtUV. EgtUV confers a competitive colonization advantage in vivo and is widely conserved in gastrointestinal microbes. Furthermore, we found that human fecal bacteria metabolize EGT, which may contribute to production of the disease-associated metabolite trimethylamine N-oxide. Collectively, our findings illustrate a previously unappreciated mechanism of microbial redox regulation in the gut and suggest that inter-kingdom competition for dietary EGT may broadly impact human health. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| Important Publications | NI Journal Papers
|
| SUSTech Authorship | Others
|
| Funding Project | National Institute of Allergy and Infectious Diseases[R01 AI22232]
; National Institutes of Health[T32 GM067543]
|
| WOS Research Area | Biochemistry & Molecular Biology
; Cell Biology
|
| WOS Subject | Biochemistry & Molecular Biology
; Cell Biology
|
| WOS Accession No | WOS:000901783200008
|
| Publisher | |
| ESI Research Field | MOLECULAR BIOLOGY & GENETICS
|
| Scopus EID | 2-s2.0-85142178546
|
| Data Source | Scopus
|
| Citation statistics |
Cited Times [WOS]:5
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/412557 |
| Department | Department of Immunology and Microbiology 生命科学学院 |
| Affiliation | 1.Department of Molecular,Cellular,and Developmental Biology,Yale University,New Haven,06520,United States 2.Department of Chemistry,Yale University,New Haven,06520,United States 3.Microbial Sciences Institute,Yale University,West Haven,06516,United States 4.Department of Microbial Pathogenesis,Yale University School of Medicine,New Haven,06520,United States 5.Department of Microbiology,Harvard Medical School,Boston,02115,United States 6.Department of Cancer Immunology and Virology,Dana-Farber Cancer Institute,Boston,02115,United States 7.Department of Molecular Biology and Microbiology,Tufts University School of Medicine,Boston,02111,United States 8.Graduate Program in Molecular Microbiology,Graduate School of Biomedical Sciences,Tufts University,Boston,02111,United States 9.Department of Immunology and Microbiology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China 10.Department of Comparative Medicine,Yale University School of Medicine,New Haven,06520,United States 11.Parker Institute for Cancer Immunotherapy at Dana-Farber Cancer Institute,Boston,02115,United States 12.Department of Molecular,Cellular,and Developmental Biology,Yale University,New Haven,06520,United States 13.Department of Chemistry,Yale University,New Haven,06520,United States 14.Microbial Sciences Institute,Yale University,West Haven,06516,United States 15.Department of Microbial Pathogenesis,Yale University School of Medicine,New Haven,06520,United States 16.Department of Microbiology,Harvard Medical School,Boston,02115,United States 17.Department of Cancer Immunology and Virology,Dana-Farber Cancer Institute,Boston,02115,United States 18.Department of Molecular Biology and Microbiology,Tufts University School of Medicine,Boston,02111,United States 19.Graduate Program in Molecular Microbiology,Graduate School of Biomedical Sciences,Tufts University,Boston,02111,United States 20.Department of Immunology and Microbiology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China 21.Department of Comparative Medicine,Yale University School of Medicine,New Haven,06520,United States 22.Parker Institute for Cancer Immunotherapy at Dana-Farber Cancer Institute,Boston,02115,United States |
| Recommended Citation GB/T 7714 |
Dumitrescu，Daniel G.,Gordon，Elizabeth M.,Kovalyova，Yekaterina,et al. A microbial transporter of the dietary antioxidant ergothioneine[J]. CELL,2022,185(24):4526-4540.e18.
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| APA |
Dumitrescu，Daniel G..,Gordon，Elizabeth M..,Kovalyova，Yekaterina.,Seminara，Anna B..,Duncan-Lowey，Brianna.,...&Hatzios，Stavroula K..(2022).A microbial transporter of the dietary antioxidant ergothioneine.CELL,185(24),4526-4540.e18.
|
| MLA |
Dumitrescu，Daniel G.,et al."A microbial transporter of the dietary antioxidant ergothioneine".CELL 185.24(2022):4526-4540.e18.
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