中文版 | English
Title

A microbial transporter of the dietary antioxidant ergothioneine

Author
Corresponding AuthorHatzios,Stavroula K.; Hatzios,Stavroula K.
Publication Years
2022-11-23
DOI
Source Title
ISSN
0092-8674
EISSN
1097-4172
Volume185Issue:24Pages:4526-4540.e18
Abstract

Low-molecular-weight (LMW) thiols are small-molecule antioxidants required for the maintenance of intracellular redox homeostasis. However, many host-associated microbes, including the gastric pathogen Helicobacter pylori, unexpectedly lack LMW-thiol biosynthetic pathways. Using reactivity-guided metabolomics, we identified the unusual LMW thiol ergothioneine (EGT) in H. pylori. Dietary EGT accumulates to millimolar levels in human tissues and has been broadly implicated in mitigating disease risk. Although certain microorganisms synthesize EGT, we discovered that H. pylori acquires this LMW thiol from the host environment using a highly selective ATP-binding cassette transporter—EgtUV. EgtUV confers a competitive colonization advantage in vivo and is widely conserved in gastrointestinal microbes. Furthermore, we found that human fecal bacteria metabolize EGT, which may contribute to production of the disease-associated metabolite trimethylamine N-oxide. Collectively, our findings illustrate a previously unappreciated mechanism of microbial redox regulation in the gut and suggest that inter-kingdom competition for dietary EGT may broadly impact human health.

Keywords
URL[Source Record]
Indexed By
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
Others
Funding Project
National Institute of Allergy and Infectious Diseases[R01 AI22232] ; National Institutes of Health[T32 GM067543]
WOS Research Area
Biochemistry & Molecular Biology ; Cell Biology
WOS Subject
Biochemistry & Molecular Biology ; Cell Biology
WOS Accession No
WOS:000901783200008
Publisher
ESI Research Field
MOLECULAR BIOLOGY & GENETICS
Scopus EID
2-s2.0-85142178546
Data Source
Scopus
Citation statistics
Cited Times [WOS]:11
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/412557
DepartmentDepartment of Immunology and Microbiology
生命科学学院
Affiliation
1.Department of Molecular,Cellular,and Developmental Biology,Yale University,New Haven,06520,United States
2.Department of Chemistry,Yale University,New Haven,06520,United States
3.Microbial Sciences Institute,Yale University,West Haven,06516,United States
4.Department of Microbial Pathogenesis,Yale University School of Medicine,New Haven,06520,United States
5.Department of Microbiology,Harvard Medical School,Boston,02115,United States
6.Department of Cancer Immunology and Virology,Dana-Farber Cancer Institute,Boston,02115,United States
7.Department of Molecular Biology and Microbiology,Tufts University School of Medicine,Boston,02111,United States
8.Graduate Program in Molecular Microbiology,Graduate School of Biomedical Sciences,Tufts University,Boston,02111,United States
9.Department of Immunology and Microbiology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
10.Department of Comparative Medicine,Yale University School of Medicine,New Haven,06520,United States
11.Parker Institute for Cancer Immunotherapy at Dana-Farber Cancer Institute,Boston,02115,United States
12.Department of Molecular,Cellular,and Developmental Biology,Yale University,New Haven,06520,United States
13.Department of Chemistry,Yale University,New Haven,06520,United States
14.Microbial Sciences Institute,Yale University,West Haven,06516,United States
15.Department of Microbial Pathogenesis,Yale University School of Medicine,New Haven,06520,United States
16.Department of Microbiology,Harvard Medical School,Boston,02115,United States
17.Department of Cancer Immunology and Virology,Dana-Farber Cancer Institute,Boston,02115,United States
18.Department of Molecular Biology and Microbiology,Tufts University School of Medicine,Boston,02111,United States
19.Graduate Program in Molecular Microbiology,Graduate School of Biomedical Sciences,Tufts University,Boston,02111,United States
20.Department of Immunology and Microbiology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
21.Department of Comparative Medicine,Yale University School of Medicine,New Haven,06520,United States
22.Parker Institute for Cancer Immunotherapy at Dana-Farber Cancer Institute,Boston,02115,United States
Recommended Citation
GB/T 7714
Dumitrescu,Daniel G.,Gordon,Elizabeth M.,Kovalyova,Yekaterina,et al. A microbial transporter of the dietary antioxidant ergothioneine[J]. CELL,2022,185(24):4526-4540.e18.
APA
Dumitrescu,Daniel G..,Gordon,Elizabeth M..,Kovalyova,Yekaterina.,Seminara,Anna B..,Duncan-Lowey,Brianna.,...&Hatzios,Stavroula K..(2022).A microbial transporter of the dietary antioxidant ergothioneine.CELL,185(24),4526-4540.e18.
MLA
Dumitrescu,Daniel G.,et al."A microbial transporter of the dietary antioxidant ergothioneine".CELL 185.24(2022):4526-4540.e18.
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