| Title | Empagliflozin activates JAK2/STAT3 signaling and protects cardiomyocytes from hypoxia/reoxygenation injury under high glucose conditions |
| Author | |
| Corresponding Author | Chen，Xiaolin |
| Publication Years | 2022
|
| DOI | |
| Source Title | |
| ISSN | 0929-5305
|
| EISSN | 1573-742X
|
| Abstract | The morbidity and mortality rates of cardiovascular disease are markedly higher in patients with diabetes than in non-diabetic patients, including patients with ischemia–reperfusion injury (IRI). However, the cardiovascular protective effects of Empagliflozin (EMPA) on IRI in diabetes mellitus have rarely been studied. In this study, we established a cardiomyocyte hypoxia/reoxygenation (H/R) injury model to mimic myocardial I/R injuries that occur in vivo. H9C2 cells were subjected to high glucose (HG) treatment plus H/R injury to mimic myocardial I/R injuries that occur in diabetes mellitus. Next, different concentrations of EMPA were added to the H9C2 cells and its protective effect was detected. STAT3 knockdown with recombinant plasmids was used to determine its roles. Our results showed that H/R injury-induced cell apoptosis, necroptosis, oxidative stress, and endoplasmic reticulum stress were further promoted by HG conditions, and HG treatment plus an H/R injury inhibited the activation of JAK2/STAT3 signaling. EMPA was found to protect against H/R-induced cardiomyocyte injury under HG conditions and activate JAK2/STAT3 signaling, while down-regulation of STAT3 reversed the protective effect of EMPA. When taken together, these findings indicate that EMPA protects against I/R-induced cardiomyocyte injury by activating JAK2/STAT3 signaling under HG conditions. Our results clarified the mechanisms that underlie the cardiovascular protective effects of EMPA in diabetes mellitus and provide new therapeutic targets for IRI in diabetes mellitus. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| WOS Accession No | WOS:000884928600001
|
| ESI Research Field | CLINICAL MEDICINE
|
| Scopus EID | 2-s2.0-85142167845
|
| Data Source | Scopus
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/412593 |
| Department | Southern University of Science and Technology |
| Affiliation | Department of Cardiology,South University of Science and Technology Hospital,Shenzhen,6019 Liuxian Avenue, Xili, Nanshan District, Guangdong,518000,China |
| First Author Affilication | Southern University of Science and Technology |
| Corresponding Author Affilication | Southern University of Science and Technology |
| First Author's First Affilication | Southern University of Science and Technology |
| Recommended Citation GB/T 7714 |
Zhang，Fan,Cao，Xudong,Zhao，Chunhui,et al. Empagliflozin activates JAK2/STAT3 signaling and protects cardiomyocytes from hypoxia/reoxygenation injury under high glucose conditions[J]. JOURNAL OF THROMBOSIS AND THROMBOLYSIS,2022.
|
| APA |
Zhang，Fan,Cao，Xudong,Zhao，Chunhui,Chen，Li,&Chen，Xiaolin.(2022).Empagliflozin activates JAK2/STAT3 signaling and protects cardiomyocytes from hypoxia/reoxygenation injury under high glucose conditions.JOURNAL OF THROMBOSIS AND THROMBOLYSIS.
|
| MLA |
Zhang，Fan,et al."Empagliflozin activates JAK2/STAT3 signaling and protects cardiomyocytes from hypoxia/reoxygenation injury under high glucose conditions".JOURNAL OF THROMBOSIS AND THROMBOLYSIS (2022).
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