中文版 | English
Title

Deciphering and Targeting Epigenetics in Cancer Metastasis

Author
Corresponding AuthorAiping Lu; Chao Liang
Publication Years
2022-08-21
ISBN
978-1-80356-162-2
Source Title
Publication Place
On-line publish
Publisher
Abstract

Once cancer metastasizes to distant organs like the bone, liver, lung, and brain, it is in an advanced stage. Metastasis is a major contributor to cancer-associated deaths.Countless molecules and complex pathways are involved in the dissemination and colonization of cancer cells from a primary tumor at metastatic sites. Establishing thebiological mechanisms of the metastatic process is crucial in finding open therapeutic windows for successful interventions. Emerging evidence suggested a variety of epigenetic regulations were identified to regulate cancer metastasis. Here we summarize the procedures and routes of cancer metastasis as well as the roles of epigeneticsincluding ncRNA, DNA methylation, and histone modifications in common metastases.Then we further discuss the potentials and limitations of epigenetics-relatedtarget molecules in diagnosis, therapy, and prognosis.

Keywords
DOI
Funding text
Natural Science Foundation Council of China (81700780 and 81922081), the Department of Education of Guangdong Province (2021KTSCX104), and the Guangdong Basic and Applied Basic Research Foundation (2022A1515012164), and the Science, Technology, and Innovation Commission of Shenzhen (JCYJ20210324104201005)
Language
English
SUSTech Authorship
First ; Corresponding
Data Source
人工提交
Publication Status
在线出版
Citation statistics
Cited Times [WOS]:0
Document TypeBook chapter
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/415490
DepartmentDepartment of Biology
生命科学学院
Affiliation
1.Department of Biology, Southern University of Science and Technology, Shenzhen, China
2.Institute of Integrated Bioinfomedicine and Translational Science (IBTS), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China
3.Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China
4.Institute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China
5.Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research, Guangzhou, China
First Author AffilicationDepartment of Biology;  School of Life Sciences
Corresponding Author AffilicationDepartment of Biology;  School of Life Sciences
Recommended Citation
GB/T 7714
Jie Huang,Aiping Lu,Chao Liang. Deciphering and Targeting Epigenetics in Cancer Metastasis. On-line publish:IntechOpen,2022.
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