中文版 | English
Title

Aftereffects of alpha transcranial alternating current stimulation over the primary sensorimotor cortex on cortical processing of pain

Author
Corresponding AuthorXiaoyun Li
Publication Years
2023-06-01
DOI
Source Title
Abstract

Transcranial alternating current stimulation (tACS) is thought to modulate brain oscillations in a frequency-specific manner. Given the correlation between sensorimotor α-oscillations and pain perception, tACS that targets sensorimotor α-oscillations has the potential to reduce pain. Therefore, this study sought to determine the aftereffects of α-tACS over unilateral primary sensorimotor cortex (SM1) on the perceptual and neural responses to noxious painful stimulation of the contralateral hand. Using a double-blinded and sham-controlled design, 60 healthy participants were recruited to receive either α-tACS or sham stimulation of unilateral SM1 through an electrode montage in a 4 × 1 ring configuration. Neural responses to laser nociceptive stimuli were assessed using functional magnetic resonance imaging (fMRI) immediately before and after α-tACS intervention. Perceptual reports were recorded simultaneously. Compared with sham stimulation, α-tACS attenuated bilateral SM1 responses to painful stimuli delivered to the contralateral hand. Although α-tACS did not exert direct effect on subjective pain perception, it can indirectly decrease ratings of pain perception by reducing brain activity within the targeted SM1. Moreover, α-tACS decreased the functional connectivity between the targeted SM1 and a network of regions that are crucially involved in pain processing, including the middle cingulate cortex, contralateral somatosensory cortex, and dorsolateral prefrontal cortex. These results demonstrated that after α-tACS applied over the unilateral SM1 does attenuate subsequent neural processing of pain within bilateral sensorimotor regions as well as sensorimotor functional connectivity. The findings provide evidence that sensorimotor α-oscillations directly affect pain processing and support the application of sensorimotor α-tACS for inducing pain analgesia.

Indexed By
Language
English
SUSTech Authorship
Others
Funding text
National Natural Science Foundation of China (31871127, 32271105, 32200900 and 62101236), and the Shenzhen Basic Research Project (JCYJ20190808154413592)
ESI Research Field
NEUROSCIENCE & BEHAVIOR
Data Source
人工提交
Publication Status
在线出版
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/415499
DepartmentDepartment of Computer Science and Engineering
Affiliation
1.School of Psychology, Shenzhen University, Shenzhen, Guangdong, China
2.Department of Computer Science and Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, China
3.Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong, China
Recommended Citation
GB/T 7714
Weiwei Peng,Yilin Zhan,Richu Jin,et al. Aftereffects of alpha transcranial alternating current stimulation over the primary sensorimotor cortex on cortical processing of pain[J]. PAIN,2023.
APA
Weiwei Peng,Yilin Zhan,Richu Jin,Wutao Lou,&Xiaoyun Li.(2023).Aftereffects of alpha transcranial alternating current stimulation over the primary sensorimotor cortex on cortical processing of pain.PAIN.
MLA
Weiwei Peng,et al."Aftereffects of alpha transcranial alternating current stimulation over the primary sensorimotor cortex on cortical processing of pain".PAIN (2023).
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