Genetic risk modifies the effect of long-term fine particulate matter exposure on coronary artery disease
|Corresponding Author||Lu，Xiangfeng; Gu，Dongfeng|
|Joint first author||Liang，Fengchao|
Background: Although both environmental and genetic factors were linked to coronary artery disease (CAD), the extent to which the association of air pollution exposure with CAD can be influenced by genetic risk was not well understood. Methods: A total of 41,149 participants recruited from the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) were included. Genetic risk scores of CAD were constructed based on 540 genetic variants. Long-term PM exposures were assessed by adopting satellite-based PM estimations at 1-km resolution. We used stratified Cox proportional hazards regression model to examine the impact of PM exposure and genetic risk on CAD risk, and further analyzed modification effect of genetic predisposition on association between PM exposure and CAD risk. Results: During a median of 13.01 years of follow-up, 1,373 incident CAD events were observed. Long-term PM exposure significantly increased CAD risk, and the hazard ratios (HRs) [95% confidence intervals (CIs)] were 1.27 (1.05–1.54) and 1.95 (1.57–2.42) among intermediate and high PM exposure groups compared to low PM exposure group. The relative risks of CAD were 40% (HR: 1.40, 95%CI: 1.18–1.66) and 133% (HR: 2.33, 95%CI: 1.94–2.79) higher among individuals at intermediate and high genetic risk than those at low genetic risk. Compared with individuals with both low genetic risk and low PM exposure, those with high genetic risk and high PM exposure had highest CAD risk, with HR of 4.37 (95%CI: 3.13–6.11). We observed significant multiplicative (P < 0.001) and additive interaction [relative excess risk due to interaction (95%CI): 2.75 (1.32–4.20); attributable proportion due to interaction (95%CI): 0.56 (0.42–0.70)] between genetic risk and PM exposure on CAD. Conclusion: This study provided evidence that long-term PM exposure might increase CAD risk, especially among people at high genetic risk. Our findings highlighted the importance of taking strategies on air quality improvement to cardiovascular disease prevention.
共同第一 ; Corresponding
National Key Research and Development Program of China[
|WOS Research Area|
Environmental Sciences & Ecology
|WOS Accession No|
|ESI Research Field|
Web of Science
Cited Times [WOS]:0
|Document Type||Journal Article|
|Department||School of Public Health and Emergency Management|
1.Department of Epidemiology,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100037,China
2.National Clinical Research Center for Cardiovascular Diseases,State Key Laboratory of Cardiovascular Epidemiology,Chinese Academy of Medical Sciences,Beijing,100037,China
3.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,518055,China
4.Tianjin Key Laboratory of Environment,Nutrition and Public Health,Department of Occupational and Environmental Health,School of Public Health,Tianjin Medical University,Tianjin,300203,China
5.Department of Epidemiology and Biostatistics,School of Public Health,Nanjing Medical University,Nanjing,211166,China
6.Department of Epidemiology and Health Statistics,College of Public Health,Zhengzhou University,Zhengzhou,450001,China
7.Department of Biostatistics and Epidemiology,School of Public Health,Shenzhen University Health Science Center,Shenzhen,518071,China
8.State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry,Institute of Atmospheric Physics,Chinese Academy of Sciences,Beijing,100029,China
9.College of Earth and Planetary Sciences,University of Chinese Academy of Sciences,Beijing,100049,China
10.School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China
|Corresponding Author Affilication||School of Medicine|
Li，Jinyue,Liang，Fengchao,Liu，Fangchao,et al. Genetic risk modifies the effect of long-term fine particulate matter exposure on coronary artery disease[J]. ENVIRONMENT INTERNATIONAL,2022,170.
Li，Jinyue.,Liang，Fengchao.,Liu，Fangchao.,Li，Jianxin.,Huang，Keyong.,...&Gu，Dongfeng.(2022).Genetic risk modifies the effect of long-term fine particulate matter exposure on coronary artery disease.ENVIRONMENT INTERNATIONAL,170.
Li，Jinyue,et al."Genetic risk modifies the effect of long-term fine particulate matter exposure on coronary artery disease".ENVIRONMENT INTERNATIONAL 170(2022).
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