RUNX Proteins as Epigenetic Modulators in Cancer
|Joint first author||Yi，Hongyang; He，Yuhao|
RUNX proteins are highly conserved in metazoans and perform critical functions during development. Dysregulation of RUNX proteins through various molecular mechanisms facilitates the development and progression of various cancers, where different RUNX proteins show tumor type-specific functions and regulate different aspects of tumorigenesis by cross-talking with different signaling pathways such as Wnt, TGF-β, and Hippo. Molecularly, they could serve as transcription factors (TFs) to activate their direct target genes or interact with many other TFs to modulate chromatin architecture globally. Here, we review the current knowledge on the functions and regulations of RUNX proteins in different cancer types and highlight their potential role as epigenetic modulators in cancer.
First ; 共同第一 ; Corresponding
Shenzhen Science and Technology Innovation Program[JCYJ20190809154407564] ; Shenzhen Science and Technology Innovation Program[KQTD20180411143432337]
|WOS Research Area|
|WOS Accession No|
Cited Times [WOS]:3
|Document Type||Journal Article|
|Department||School of Life Sciences|
1.Shenzhen Key Laboratory of Gene Regulation and Systems Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518055,China
2.Department of Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518055,China
3.National Clinical Research Centre for Infectious Diseases,The Third People’s Hospital of Shenzhen,The Second Affiliated Hospital of Southern University of Science and Technology,Shenzhen,518112,China
4.Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,518005,China
|First Author Affilication||School of Life Sciences; Department of Biology; The Third People's Hospital of Shenzhen|
|Corresponding Author Affilication||School of Life Sciences; Department of Biology; Academy for Advanced Interdisciplinary Studies|
|First Author's First Affilication||School of Life Sciences|
Yi，Hongyang,He，Yuhao,Zhu，Qionghua,et al. RUNX Proteins as Epigenetic Modulators in Cancer[J]. Cells,2022,11(22).
Yi，Hongyang,He，Yuhao,Zhu，Qionghua,&Fang，Liang.(2022).RUNX Proteins as Epigenetic Modulators in Cancer.Cells,11(22).
Yi，Hongyang,et al."RUNX Proteins as Epigenetic Modulators in Cancer".Cells 11.22(2022).
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