| Title | Asymmetric organocatalytic (3 + 2) annulation of propargylic alcohols with indolylnaphthalenols: synergistic construction of axial and central chirality |
| Author | |
| Corresponding Author | Li，Pengfei; Dong，Mingxin; Li，Wenjun |
| Publication Years | 2022
|
| DOI | |
| Source Title | |
| ISSN | 2052-4110
|
| EISSN | 2052-4129
|
| Abstract | Organocatalytic enantioselective construction of chiral spiro N,N-acetal carbon stereocenters and axially chiral 3-arylindoles has been achieved via a chiral phosphoric acid (CPA)-catalyzed (3 + 2) annulation of α-(3-isoindolinonyl) propargylic alcohols with 1-(3-indolyl)naphthalen-2-ols, affording a broad scope of pyrrolo[1,2-a]indoles bearing both enantioenriched spiro isoindolinone-indoline and atropisomeric naphthalenol frameworks. Based on control experiments and our previous work, a possible mechanism was proposed accordingly. |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| Funding Project | [ZR2021MB026]
; [tsqn201812047]
; [20200925151614002]
; [2020B121201002]
|
| WOS Research Area | Chemistry
|
| WOS Subject | Chemistry, Organic
|
| WOS Accession No | WOS:000885655000001
|
| Publisher | |
| Scopus EID | 2-s2.0-85142453396
|
| Data Source | Scopus
|
| Citation statistics |
Cited Times [WOS]:1
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/415757 |
| Department | Department of Chemistry 理学院 深圳格拉布斯研究院 |
| Affiliation | 1.Department of Medicinal Chemistry,School of Pharmacy,Qingdao University,Qingdao,Shandong,266021,China 2.Shenzhen Grubbs Institute and Department of Chemistry,Guangdong Provincial Key Laboratory of Catalysis,College of Science,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China |
| Corresponding Author Affilication | Department of Chemistry; Shenzhen Grubbs Institute; College of Science |
| Recommended Citation GB/T 7714 |
Xia，Yan,Liu，Meiwen,Qian，Chenxiao,et al. Asymmetric organocatalytic (3 + 2) annulation of propargylic alcohols with indolylnaphthalenols: synergistic construction of axial and central chirality[J]. Organic Chemistry Frontiers,2022.
|
| APA |
Xia，Yan,Liu，Meiwen,Qian，Chenxiao,Li，Pengfei,Dong，Mingxin,&Li，Wenjun.(2022).Asymmetric organocatalytic (3 + 2) annulation of propargylic alcohols with indolylnaphthalenols: synergistic construction of axial and central chirality.Organic Chemistry Frontiers.
|
| MLA |
Xia，Yan,et al."Asymmetric organocatalytic (3 + 2) annulation of propargylic alcohols with indolylnaphthalenols: synergistic construction of axial and central chirality".Organic Chemistry Frontiers (2022).
|
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