Roles of focal adhesion proteins in skeleton and diseases

Sheng Chen1,2; Tailin He2; Yiming Zhong2; Mingjue Chen2; Qing Yao2; Di Chen3; Zengwu Shao1; Guozhi Xiao2

2023-03-01

10.1016/j.apsb.2022.09.020

ACTA PHARMACEUTICA SINICA B   Impact Factor & Quartile

2211-3835

2211-3843

The skeletal system, which contains bones, joints, tendons, ligaments and other elements, plays a wide variety of roles in body shaping, support and movement, protection of internal organs, pro-duction of blood cells and regulation of calcium and phosphate metabolism. The prevalence of skeletal diseases and disorders, such as osteoporosis and bone fracture, osteoarthritis, rheumatoid arthritis, and intervertebral disc degeneration, increases with age, causing pain and loss of mobility and creating a huge social and economic burden globally. Focal adhesions (FAs) are macromolecular assemblies that are composed of the extracellular matrix (ECM), integrins, intracellular cytoskeleton and other proteins, including kindlin, talin, vinculin, paxillin, pinch, Src, focal adhesion kinase (FAK) and integrin-linked protein kinase (ILK) and other proteins. FA acts as a mechanical linkage connecting the ECM and cyto-skeleton and plays a key role in mediating cell-environment communications and modulates important processes, such as cell attachment, spreading, migration, differentiation and mechanotransduction, in different cells in skeletal system by impacting distinct outside-in and inside-out signaling pathways. This review aims to integrate the up-to-date knowledge of the roles of FA proteins in the health and disease of skeletal system and focuses on the specific molecular mechanisms and underlying therapeutic targets for skeletal diseases.

Focal adhesion Skeleton Mechanotransduction Signal transduction Integrin Cartilage Intervertebral disc Skeletal diseases

SCI

English

Corresponding

National Key Research and Development Program of China[2019YFA0906004] ; National Natural Science Foundation of China["82230081","82250710175","81991513","81870532"] ; Guangdong Provincial Science and Technology Innovation Council (China)[2017B030301018] ; Shenzhen Municipal Science and Technology Innovation Council (China)[20200925150409001]

Pharmacology & Pharmacy

Pharmacology & Pharmacy

WOS:000962471600001

INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES

Web of Science

1.Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
2.Department of Biochemistry, School of Medicine, Shenzhen Key Laboratory of Cell Microenvironment, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Southern University of Science and Technology, Shenzhen 518055, China
3.Research Center for Human Tissues and Organs Degeneration, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

Sheng Chen,Tailin He,Yiming Zhong,et al. Roles of focal adhesion proteins in skeleton and diseases[J]. ACTA PHARMACEUTICA SINICA B,2023,13(3).

Sheng Chen.,Tailin He.,Yiming Zhong.,Mingjue Chen.,Qing Yao.,...&Guozhi Xiao.(2023).Roles of focal adhesion proteins in skeleton and diseases.ACTA PHARMACEUTICA SINICA B,13(3).

Sheng Chen,et al."Roles of focal adhesion proteins in skeleton and diseases".ACTA PHARMACEUTICA SINICA B 13.3(2023).