中文版 | English
Title

Secretin receptor deletion in the subfornical organ attenuates the activation of excitatory neurons under dehydration

Author
Corresponding AuthorYung Wing Ho; Zhang Li; Chow Billy Kwok Chong
Publication Years
2022-11-21
DOI
Source Title
ISSN
0960-9822
EISSN
1879-0445
Volume32Issue:22
Abstract
In mammals, thirst is strongly influenced by the subfornical organ (SFO), a forebrain structure that integrates circulating signals including osmotic pressure and sodium contents. Secretin (SCT), a classical gastrointestinal hormone, has been implicated as a humoral factor regulating body-fluid homeostasis. However, the neural mechanism of secretin in the central nervous system in managing thirst remains unclear. In this study, we report that the local ablation of SCT receptor (SCTR) in the SFO reduces water but not salt intake in dehydrated mice and this effect could not be rescued by exogenous SCT administration. Electrophysiology with single-cell RT-PCR indicates that SCT elicits inward currents in the SFO neuronal nitric oxide synthase (SFOnNOS) neurons via SCTR in the presence of glutamate receptor antagonists. We further show that the SCTR in the SFO permits the activation of SFOnNOS neurons under distinct thirst types. Projection-specific gene deletion of SCTR in SFO to the median preoptic nucleus (MnPO) pathway also reduces water intake in dehydrated animals. SCT signaling thus plays an indispensable role in driving thirst. These data not only expand the functional boundaries of SCTR but also provide insights into the central mechanisms of homeostatic regulation.
URL[Source Record]
Indexed By
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
Others
Funding Project
Shenzhen Municipal Government["JCYJ20170412153517422","KQJSCX20180322152418316"] ; National Natural Science Foundation of China[32070955] ; Hong Kong Government["GRF 17127718","GRF 17113120","GRF 17126222"]
WOS Research Area
Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
WOS Subject
Biochemistry & Molecular Biology ; Biology ; Cell Biology
WOS Accession No
WOS:000946528100005
Publisher
ESI Research Field
BIOLOGY & BIOCHEMISTRY
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/416230
DepartmentDepartment of Biology
生命科学学院
Affiliation
1.School of Biological Sciences, The University of Hong Kong
2.School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong
3.Gerald Choa Neuroscience Centre, The Chinese University of Hong Kong
4.School of Life Sciences, Department of Biology, Southern University of Science and Technology
5.Key Laboratory of CNS Regeneration (Ministry of Education), GHM Institute of CNS Regeneration, Jinan University
6.Neuroscience and Neurorehabilitation Institute, University of Health and Rehabilitation Sciences
Recommended Citation
GB/T 7714
Zhang Fengwei,Mak Sarah O.K.,Liu Yuchu,et al. Secretin receptor deletion in the subfornical organ attenuates the activation of excitatory neurons under dehydration[J]. CURRENT BIOLOGY,2022,32(22).
APA
Zhang Fengwei.,Mak Sarah O.K..,Liu Yuchu.,Ya Ke.,Rao Feng.,...&Chow Billy Kwok Chong.(2022).Secretin receptor deletion in the subfornical organ attenuates the activation of excitatory neurons under dehydration.CURRENT BIOLOGY,32(22).
MLA
Zhang Fengwei,et al."Secretin receptor deletion in the subfornical organ attenuates the activation of excitatory neurons under dehydration".CURRENT BIOLOGY 32.22(2022).
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