Transition-metal-catalyzed enantioselective C−H silylation

Ge，Yicong1,2; Huang，Xingfen1; Ke，Jie1; He，Chuan1

2022-11-17

10.1016/j.checat.2022.07.009

Chem Catalysis   Impact Factor & Quartile

2667-1107

2667-1093

Organosilanes are important and valuable compounds that have found widespread applications in the fields of organic chemistry, agrochemistry, medicinal chemistry, and materials science. In modern synthetic chemistry, molecules featuring carbon−silicon bonds have attracted considerable interest given that these motifs can be efficiently converted to a wide range of functionalities. Among various approaches, transition-metal-catalyzed C−H silylation has emerged as a powerful tool for the synthesis of silicon-containing functional molecules, which has profoundly accelerated the iteration of organosilicon science. Despite the rapid development of C−H silylation, the enantioselective version of this elegant methodology was not known until 2013. In this review, we aim to summarize recent advances in the area of enantioselective C−H silylation mediated by chiral transition-metal catalysts, organized by the different forms of chirality of the enantioenriched organosilanes. We highlight the great potential of this methodology and intend to inspire further research and applications in this emerging area.

asymmetric catalysis chiral silanes enantioselective C−H silylation SDG3: Good health and well-being SDG7: Affordable and clean energy SDG9: Industry innovation and infrastructure Si-CADC transition-metal catalysis

English

First ; Corresponding

Guangdong Provincial Key Laboratory Of Catalysis[2020B121201002];National Natural Science Foundation of China[21901104];National Natural Science Foundation of China[22101113];National Natural Science Foundation of China[22101120];National Natural Science Foundation of China[22122102];

2-s2.0-85141990313

Scopus

1.Shenzhen Grubbs Institute and Department of Chemistry,Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen,Guangdong,518055,China
2.Sichuan Province Key Laboratory of Natural Products and Small Molecule Synthesis,School of New Energy Materials and Chemistry,Leshan Normal University,Leshan,Sichuan,614000,China

Ge，Yicong,Huang，Xingfen,Ke，Jie,et al. Transition-metal-catalyzed enantioselective C−H silylation[J]. Chem Catalysis,2022,2(11):2898-2928.

Ge，Yicong,Huang，Xingfen,Ke，Jie,&He，Chuan.(2022).Transition-metal-catalyzed enantioselective C−H silylation.Chem Catalysis,2(11),2898-2928.

Ge，Yicong,et al."Transition-metal-catalyzed enantioselective C−H silylation".Chem Catalysis 2.11(2022):2898-2928.